Analysis Tools
reproductive system
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• reduced productive matings, number of litters, and litter size
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• smaller and fewer liters with increased litter interval
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behavior/neurological
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• less anxious in social interactions
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• reduced innate fear phenotype in the elevated plus-maze, open field, social interaction, and novelty suppressed feeding tests
• no significant difference in learned-fear response compared to control
• homozygous mice shows no abnormalities in weight, spontaneous behavior, neurological reflexes. or sensorimotor responses including righting, postural reflex, ear twitch reflex, grip strength, and whisker orientation reflex
• no impairment in overall spontaneous locomotor activity
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• froze more commonly in response under certain training condition
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nervous system
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• Th+ ARC neurons exhibit reduced interburst intervals and enhanced instantaneous burst frequencies, increased variability of Vu and reduced burst strength causing a reduction in both depolarization envelope and spike frequency within a burst compared with wild-type cells
• Th+ ARC neurons exhibit loss of prolactin-evoked tonic excitation unlike wild-type mice
• however, rhythmic activity in the presence of prolactin remains intake
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• diminished synaptic strength in lateral nucleus of the amygdala (LA) neuron
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homeostasis/metabolism
