Phenotypes associated with this allele

• Allele Symbol: Rbm15^{tm1.1(MAL)Dgg}
• Allele Name: targeted mutation 1.1, D Gilliland
• Allele ID: MGI:3849068
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbm15^tm1.1(MAL)Dgg/Rbm15^tm1.1(MAL)Dgg	B6.129-Rbm15^tm1.1(MAL)Dgg	MGI:3849073

Genotype
MGI:3849073

hm1

• Allelic Composition: Rbm15^{tm1.1(MAL)Dgg}/Rbm15^{tm1.1(MAL)Dgg}
• Genetic Background: B6.129-Rbm15^{tm1.1(MAL)Dgg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:149622 )

♀ • at E12.5, fetal livers exhibit an expansion of multipotent myeloid progenitors compared with wild-type livers

♀ • however, the number of hematopoietic progenitor cells is normal

extramedullary hematopoiesis ( J:149622 )

♀ • in the liver at 18 to 24 months

increased hematopoietic stem cell number ( J:149622 )

♀ • at E12.5, the number of LSK hematopoietic cells is increased compared to in wild-type mice with an increase in both CFU-GEMM and CFU-Mk

♀ • at 18 to 24 months, the number of progenitors in splenocytes is increased compared to in wild-type mice and increased replating activity

neoplasm

increased leukemia incidence ( J:149622 )

♀ • 2 of 15 mice develop frank leukemia and exhibit infiltration of the bone marrow, spleen, liver, and kidney with an admixture of immature megakaryocytic and erythroid elements as well as megakaryoblasts circulating in the peripheral blood

♀ • leukemia is transplantable