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Allele Symbol Allele Name Allele ID |
Tg(CAG-Nog)1Ych transgene insertion 1, YiPeng Chen MGI:3848915 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• myofibers in the levator veli palatini are reduced and sparser compared to controls
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• myofibers in the palatopharyngeus are reduced and sparser compared to controls
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• myofibers in the tensor veli palatini are reduced and sparser compared to controls
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• at E17.5 the soft palate is still separated at the palatopharyngeus level but fused at the level of the levator veli palatini and tensor veli palatini muscles
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• myofibers in the levator veli palatini are reduced and sparser compared to controls
|
|
• myofibers in the palatopharyngeus are reduced and sparser compared to controls
|
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• myofibers in the tensor veli palatini are reduced and sparser compared to controls
|
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• myofibers in the superior pharyngeal constrictor are reduced and sparser compared to controls
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• myofibers in the levator veli palatini are reduced and sparser compared to controls
|
|
• myofibers in the palatopharyngeus are reduced and sparser compared to controls
|
|
• myofibers in the tensor veli palatini are reduced and sparser compared to controls
|
|
• at E17.5 the soft palate is still separated at the palatopharyngeus level but fused at the level of the levator veli palatini and tensor veli palatini muscles
|
|
• myofibers in the levator veli palatini are reduced and sparser compared to controls
|
|
• myofibers in the palatopharyngeus are reduced and sparser compared to controls
|
|
• myofibers in the tensor veli palatini are reduced and sparser compared to controls
|
|
• at E17.5 the soft palate is still separated at the palatopharyngeus level but fused at the level of the levator veli palatini and tensor veli palatini muscles
|
|
• myofibers in the superior pharyngeal constrictor are reduced and sparser compared to controls
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• shelves are separated from each other and smaller at E14.5 and E16.5
• extraversive hypophosphatasia
• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5
• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels
• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate
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• hypoplastic muscle tissue
|
|
• expression analysis indicates impaired development of the aponeurosis of the soft palate
|
|
• only a few sparsely distributed myofibers are present at E14.5
• at E16.5, myofibers become even looser and shorter compared to E14.5
|
|
• at E16.5 the palatopharyngeus is smaller with fewer myofibers
|
|
• mildly smaller at E14.5 and dramatically smaller at E16.5
|
|
• only a few sparsely distributed myofibers are present at E14.5
• at E16.5, myofibers become even looser and shorter compared to E14.5
|
|
• at E16.5 the palatopharyngeus is smaller with fewer myofibers
|
|
• mildly smaller at E14.5 and dramatically smaller at E16.5
|
|
• at E16.5 the superior pharyngeal constrictor is smaller with fewer myofibers
|
|
• shelves are separated from each other and smaller at E14.5 and E16.5
• extraversive hypophosphatasia
• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5
• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels
• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate
|
|
• hypoplastic muscle tissue
|
|
• expression analysis indicates impaired development of the aponeurosis of the soft palate
|
|
• only a few sparsely distributed myofibers are present at E14.5
• at E16.5, myofibers become even looser and shorter compared to E14.5
|
|
• at E16.5 the palatopharyngeus is smaller with fewer myofibers
|
|
• mildly smaller at E14.5 and dramatically smaller at E16.5
|
|
• shelves are separated from each other and smaller at E14.5 and E16.5
• extraversive hypophosphatasia
• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5
• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels
• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate
|
|
• hypoplastic muscle tissue
|
|
• expression analysis indicates impaired development of the aponeurosis of the soft palate
|
|
• only a few sparsely distributed myofibers are present at E14.5
• at E16.5, myofibers become even looser and shorter compared to E14.5
|
|
• at E16.5 the palatopharyngeus is smaller with fewer myofibers
|
|
• mildly smaller at E14.5 and dramatically smaller at E16.5
|
|
• at E16.5 the superior pharyngeal constrictor is smaller with fewer myofibers
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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