Phenotypes associated with this allele
limbs/digits/tail
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• at P1, digits appear posteriorized comparing relative digit length and phalanx morphology with that of controls Shhtm1Amc/Shhtm2Amc Tg(Prrx1-cre)1Cjt mice
• however, mice have the same number of digits as in Shhtm1Amc/Shhtm2Amc Tg(Prrx1-cre)1Cjt mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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limbs/digits/tail
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• less well-formed ectopic cartilaginous elements are observed in the anterior limb unlike in wild-type mice
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• the most anterior digit contains three phalanges instead of the normal two
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• mice have 6 to 7 digits unlike in wild-type mice
• in some cases, the ectopic digit is more centrally located and consists of three phalangeal elements without an additional metacarpal element
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skeleton
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• the most anterior digit contains three phalanges instead of the normal two
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation
(0 available);
any
Fgfr1 mutation
(221 available)
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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limbs/digits/tail
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• at P1, mice exhibit a more severe zeugopod phenotypes than in Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+ Tg(Prrx1-cre)1Cjt mice
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