Analysis Tools
reproductive system
endocrine/exocrine glands
cellular
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Allele Symbol Allele Name Allele ID |
Nxf2tm1.2Jw targeted mutation 1.2, Jeremy Wang MGI:3848439 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4 of 6 male mice sire 1 to 3 litters before becoming infertile unlike wild-type mice
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N |
• Background Sensitivity: on a congenic C57BL/6J background, meiosis progression is normal unlike on a mixed 129/Sv and C57BL/6 background
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• mice exhibit an age-dependent loss of spermatogonia unlike wild-type mice
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• at 9 months, 26% of seminiferous tubules lack germ cells unlike in wild-type mice
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• the percentage of motile sperm is decreased compared to in wild-type mice
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• smaller in diameter
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• 30% at 2 months
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• 4 of 6 male mice sire 1 to 3 litters before becoming infertile unlike wild-type mice
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• impaired at 2.5 months of age
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• epididymides contain half the number of sperm as in wild-type mice
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• reduced
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• from male mice
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• 2 of 6 males are sterile
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• 4 of 6 male mice sire 1 to 3 litters before becoming infertile unlike wild-type mice
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• smaller in diameter
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• 30% at 2 months
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• mice exhibit an age-dependent loss of spermatogonia unlike wild-type mice
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• at 9 months, 26% of seminiferous tubules lack germ cells unlike in wild-type mice
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• epididymides contain half the number of sperm as in wild-type mice
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• the percentage of motile sperm is decreased compared to in wild-type mice
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• reduced
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• female mice exhibit normal fertility
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• anaphase cells exhibit chromosome segregation is chaotic unlike in wild-type mice
• Background Sensitivity: on a mixed 129/Sv and C57BL/6 background, progression of meiosis is impaired unlike on a congenic C57BL/6J background
• however, the number of chromosome crossover sites is normal
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• in males with small testes
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• in one third of mice
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• at Stage XII of spermatogenesis in one third of mice
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• in 29% of mice
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• one third of male mice are infertile unlike wild-type mice
• however, remaining mice exhibit normal fertility
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• in 29% of mice
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• anaphase cells exhibit chromosome segregation is chaotic unlike in wild-type mice
• Background Sensitivity: on a mixed 129/Sv and C57BL/6 background, progression of meiosis is impaired unlike on a congenic C57BL/6J background
• however, the number of chromosome crossover sites is normal
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• in males with small testes
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• in one third of mice
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• at Stage XII of spermatogenesis in one third of mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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