Phenotypes associated with this allele

• Allele Symbol: Plrg1^tm2Jcbr
• Allele Name: targeted mutation 2, Jens C Bruning
• Allele ID: MGI:3848231
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plrg1^tm2Jcbr/Plrg1^tm2Jcbr	Not Specified	MGI:3848248
cn2	Plrg1^tm2Jcbr/Plrg1^tm2Jcbr Tg(Syn1-cre)671Jxm/0	involves: C57BL/6 * CBA	MGI:3848250
cn3	Plrg1^tm2Jcbr/Plrg1^tm2Jcbr Tg(Ckmm-cre)5Khn/0	involves: FVB	MGI:3848249

Genotype
MGI:3848248

hm1

• Allelic Composition: Plrg1^tm2Jcbr/Plrg1^tm2Jcbr
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:149153 )

• cre-treated mouse embryonic fibroblasts fail to progress beyond S-phase

decreased cell proliferation ( J:149153 )

• cre-treated mouse embryonic fibroblasts (MEFs) cease to proliferate immediately

• cre-treated MEFs fail to respond to serum stimulation

Genotype
MGI:3848250

cn2

• Allelic Composition: Plrg1^tm2Jcbr/Plrg1^tm2Jcbr; Tg(Syn1-cre)671Jxm/0
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

postnatal lethality, complete penetrance ( J:149153 )

• survival at P3 is 25% compared to 88% for wild-type mice

• all mice die by P9

nervous system

increased neuron apoptosis ( J:149153 )

cellular

increased neuron apoptosis ( J:149153 )

Genotype
MGI:3848249

cn3

• Allelic Composition: Plrg1^tm2Jcbr/Plrg1^tm2Jcbr; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: FVB

mortality/aging

premature death ( J:149153 )

• survival at P28 is 5% compared to 80% for wild-type mice

cardiovascular system

abnormal heart ventricle morphology ( J:149153 )

• at P24, both ventricles exhibit atrophy unlike in wild-type mice

thin ventricular wall ( J:149153 )

dilated heart ( J:149153 )

dilated heart left ventricle ( J:149153 )

• at P24

dilated heart right ventricle ( J:149153 )

• at P24

dilated cardiomyopathy ( J:149153 )

decreased ventricle muscle contractility ( J:149153 )

increased cardiomyocyte apoptosis ( J:149153 )

muscle

dilated cardiomyopathy ( J:149153 )

decreased ventricle muscle contractility ( J:149153 )

increased cardiomyocyte apoptosis ( J:149153 )

cellular

increased cardiomyocyte apoptosis ( J:149153 )