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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nkx3-2tm1(cre)Wez
targeted mutation 1, Warren E Zimmer
MGI:3848005
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nkx3-2tm1(cre)Wez/Nkx3-2tm1(cre)Wez involves: 129S7/SvEvBrd * C57BL/6 MGI:3848515
cn2
 		Smotm2Amc/Smotm2Amc
Nkx3-2tm1(cre)Wez/Nkx3-2+ 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:5518634
cn3
 		Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Smotm2Amc/Smotm2Amc
Nkx3-2tm1(cre)Wez/Nkx3-2+ 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:5518632
cn4
 		Gli3tm1Alj/Gli3tm1Alj
Nkx3-2tm1(cre)Wez/Nkx3-2+ 		involves: 129S6/SvEvTac * 129S7/SvEvBrd MGI:5518635
cn5
 		Gli3tm1Alj/Gli3tm1Alj
Nkx3-2tm1(cre)Wez/Nkx3-2+
Smotm2Amc/Smotm2Amc 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ MGI:5518637
cn6
 		Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Nkx3-2tm1(cre)Wez/Nkx3-2+ 		involves: 129S7/SvEvBrd MGI:5518631
cn7
 		Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Nkx3-2tm1(cre)Wez/Nkx3-2+ 		involves: 129S7/SvEvBrd * 129X1/SvJ MGI:5518633


Genotype
MGI:3848515
hm1
Allelic
Composition		 Nkx3-2tm1(cre)Wez/Nkx3-2tm1(cre)Wez
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-2tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
absent basioccipital bone ( J:148724 )
• loss of this bone of the cranial vault is observed at E18.5
absent basisphenoid bone ( J:148724 )
• observed at E18.5

skeleton
abnormal skeleton morphology ( J:148724 )
• skeletons are defective; skeletal anomalies are similar to those reported for other Nkx3-2 null homozygotes
absent basioccipital bone ( J:148724 )
• loss of this bone of the cranial vault is observed at E18.5
absent basisphenoid bone ( J:148724 )
• observed at E18.5
abnormal vertebral column morphology ( J:148724 )
• absence of midline structures in vertebral column is observed in E18.5 embryos




Genotype
MGI:5518634
cn2
Allelic
Composition		 Smotm2Amc/Smotm2Amc
Nkx3-2tm1(cre)Wez/Nkx3-2+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-2tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)
Smotm2Amc mutation (1 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Intestinal mesenchymal proliferation and expansion are affected in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

mortality/aging
neonatal lethality, complete penetrance ( J:199664 )
• mice die immediately after birth

digestive/alimentary system
abnormal intestinal goblet cell morphology ( J:199664 )
• lack of Goblet and enteroendocrine cell lineage differentiation at E18.5
abnormal intestine development ( J:199664 )
• at E18.5, mice exhibit fewer mesenchyme cells between thin layers of mesentery and intestinal epithelium compared with control mice
abnormal intestinal enteroendocrine cell morphology ( J:199664 )
• lack of Goblet and enteroendocrine cell lineage differentiation at E18.5
abnormal intestinal smooth muscle morphology ( J:199664 )
• decreased SMA+ or Desmin+ intestinal smooth muscle cells
abnormal intestine physiology ( J:199664 )
• absent intestinal mesenchymal proliferation
abnormal enterocyte proliferation ( J:199664 )
• intestinal epithelium do not proliferate at E18.5

muscle
abnormal intestinal smooth muscle morphology ( J:199664 )
• decreased SMA+ or Desmin+ intestinal smooth muscle cells

cellular
abnormal intestinal goblet cell morphology ( J:199664 )
• lack of Goblet and enteroendocrine cell lineage differentiation at E18.5
abnormal enterocyte proliferation ( J:199664 )
• intestinal epithelium do not proliferate at E18.5

nervous system
abnormal enteric neuron morphology ( J:199664 )
• decreased population




Genotype
MGI:5518632
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Smotm2Amc/Smotm2Amc
Nkx3-2tm1(cre)Wez/Nkx3-2+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Gli2)Jmao mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Nkx3-2tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)
Smotm2Amc mutation (1 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

digestive/alimentary system
digestive/alimentary phenotype ( J:199664 )
N
• intestinal development is rescued




Genotype
MGI:5518635
cn4
Allelic
Composition		 Gli3tm1Alj/Gli3tm1Alj
Nkx3-2tm1(cre)Wez/Nkx3-2+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3tm1Alj mutation (1 available); any Gli3 mutation (80 available)
Nkx3-2tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

mortality/aging
mortality/aging ( J:199664 )
N
• mice are born at the expected Mendelian ratios

digestive/alimentary system
digestive/alimentary phenotype ( J:199664 )
N
• mice exhibit normal intestinal development




Genotype
MGI:5518637
cn5
Allelic
Composition		 Gli3tm1Alj/Gli3tm1Alj
Nkx3-2tm1(cre)Wez/Nkx3-2+
Smotm2Amc/Smotm2Amc
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3tm1Alj mutation (1 available); any Gli3 mutation (80 available)
Nkx3-2tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)
Smotm2Amc mutation (1 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

digestive/alimentary system
abnormal digestive system morphology ( J:199664 )
• mice exhibit the same defects as in Nkx3-2tm1(cre)Wez/Nkx3-2+ Smom2Amc/Smom2Amc mice




Genotype
MGI:5518631
cn6
Allelic
Composition		 Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Nkx3-2tm1(cre)Wez/Nkx3-2+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Gli2)Jmao mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Nkx3-2tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

digestive/alimentary system
digestive/alimentary phenotype ( J:199664 )
N
• mice exhibit normal intestinal development




Genotype
MGI:5518633
cn7
Allelic
Composition		 Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Nkx3-2tm1(cre)Wez/Nkx3-2+
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Nkx3-2tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestine development ( J:199664 )
• intestinal mesenchymal compartment is expanded




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory