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Allele Symbol Allele Name Allele ID |
Eif3ftm1(KOMP)Vlcg targeted mutation 1, Velocigene MGI:3847510 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no homozygous mutants are recovered at birth following heterozygous intercrosses
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• presence of empty decidua suggests that homozygous mutants die at an early post-implantation embryonic stage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• less than expected heterozygotes are born from heterozygous intercrosses (39% instead of 66%) and from crosses between heterozygous and wild-type mice (37% instead of 50%)
• crosses between male or female heterozygotes and wild-type mice revealed that heterozygous lethality is not associated with the production of dysfunctional spermatozoa or oocytes
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• at 4-6 months of age, heterozygotes show decreased lean body mass
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• at 4 months of age, skeletal muscles of heterozygous mice show a reduction of muscle fiber size (tibialis, -21%; gastrocnemius, -24%; soleus, -26%; EDL, -17%)
• however, total fiber number and fiber type remain unaffected
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• adult heterozygotes show reduced skeletal muscle mass; EDL, tibialis, quadriceps, gastrocnemius and soleus muscle mass is reduced by 14-18% relative to that in wild-type controls
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• during hindlimb immobilization, heterozygotes show an exacerbated immobilization-induced skeletal muscle atrophy associated with reduced protein synthesis and reduced phosphorylation of S6K1 and S6 proteins relative to wild-type controls
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• skeletal muscles of heterozygous mice show a deficiency in polysome content, a reduction in protein synthesis rate and an inhibition of the mechanistic target of rapamycin (MTOR) pathway
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• decreased skeletal muscle mass is associated with a reduction in the protein synthesis rate and an inhibition of the MTORC1 pathway
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• decreased skeletal muscle mass is associated with a reduction in the protein synthesis rate and an inhibition of the MTORC1 pathway
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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