Phenotypes associated with this allele

• Allele Symbol: Tg(Camk2a-cre)62Jzt
• Allele Name: transgene insertion 62, Joe Z Tsien
• Allele ID: MGI:3847114
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pparg^tm2Rev/Pparg^tm2Rev Tg(Camk2a-cre)62Jzt/?	B6.Cg-Pparg^tm2Rev Tg(Camk2a-cre)62Jzt	MGI:5444199
cn2	Grin1^tm2Stl/Grin1^tm2Stl Tg(Actb-tTA)1Jzt/0 Tg(Camk2a-cre)62Jzt/0 Tg(tetO-Grin1/GFP)1Jzt/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:3847227

Genotype
MGI:5444199

cn1

• Allelic Composition: Pparg^tm2Rev/Pparg^tm2Rev; Tg(Camk2a-cre)62Jzt/?
• Genetic Background: B6.Cg-Pparg^tm2Rev Tg(Camk2a-cre)62Jzt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:148757 )

N • gross brain structures are normal and overall appearance is normal

abnormal neuron physiology ( J:148757 )

• neurons in culture suffer more severe damage from oxygen-glucose deprivation than controls

• more susceptible to H2O2 induced injury than controls

brain ischemia ( J:148757 )

• develop 40% larger infarctions after middle cerebral artery occlusion

• increased neurological dysfunction as well

• mortality not affected

growth/size/body

growth/size/body region phenotype ( J:148757 )

N • growth and body weight are normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:148757 )

N • normal body temperature

behavior/neurological

behavior/neurological phenotype ( J:148757 )

N • activity is normal

Genotype
MGI:3847227

cn2

• Allelic Composition: Grin1^tm2Stl/Grin1^tm2Stl; Tg(Actb-tTA)1Jzt/0; Tg(Camk2a-cre)62Jzt/0; Tg(tetO-Grin1/GFP)1Jzt/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

behavior/neurological

abnormal learning/memory/conditioning ( J:100903 )

• consolidation and storage of long-term nondeclarative taste memories is impaired in these mice when given doxycycline prior to or within three weeks of training

abnormal conditioned taste aversion behavior ( J:100903 )

• mice given doxycycline have impairment of conditioned taste aversion

• mice are trained to avoid saccharin-containing water by being given a LiCl injection after water consumption

• control mice choose unsweetened water about 83.58% of the time 30 days after training

• mutant mice given doxycycline prior to training only choose unsweetened water 32.24% of the time

• mutant mice given doxycycline 2 weeks after training choose unsweetened water 25.63% of the time

• mutant mice given doxycycline 3 weeks to 4 weeks after training choose unsweetened water 27.99% of the time

• mutant mice given doxycycline 4 weeks after training choose unsweetened water at the same frequency as controls