All Phenotypes Tpt1<tm1Kefu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tpt1^tm1Kefu
targeted mutation 1, Ken Fujise
MGI:3846761

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpt1^tm1Kefu/Tpt1^tm1Kefu	129S6/SvEvTac-Tpt1^tm1Kefu	MGI:3846782
hm2	Tpt1^tm1Kefu/Tpt1^tm1Kefu	B6.129S6-Tpt1^tm1Kefu	MGI:3846781
hm3	Tpt1^tm1Kefu/Tpt1^tm1Kefu	either: 129S6/SvEvTac-Tpt1^tm1Kefu or B6.129S6-Tpt1^tm1Kefu	MGI:3846778
hm4	Tpt1^tm1Kefu/Tpt1^tm1Kefu	involves: 129S6/SvEvTac * C57BL/6	MGI:3846780
ht5	Tpt1^tm1Kefu/Tpt1⁺	either: 129S6/SvEvTac-Tpt1^tm1Kefu or B6.129S6-Tpt1^tm1Kefu	MGI:3846779

Allelic Composition	Tpt1^tm1Kefu/Tpt1^tm1Kefu
Genetic Background	129S6/SvEvTac-Tpt1^tm1Kefu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpt1^tm1Kefu mutation (0 available); any Tpt1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:148696 )

• no mice are born alive

Allelic Composition	Tpt1^tm1Kefu/Tpt1^tm1Kefu
Genetic Background	B6.129S6-Tpt1^tm1Kefu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpt1^tm1Kefu mutation (0 available); any Tpt1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:148696 )

• no mice are born alive

Allelic Composition	Tpt1^tm1Kefu/Tpt1^tm1Kefu
Genetic Background	either: 129S6/SvEvTac-Tpt1^tm1Kefu or B6.129S6-Tpt1^tm1Kefu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpt1^tm1Kefu mutation (0 available); any Tpt1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:148696 )

• fewer than expected mice are found at E3.5

embryonic lethality between implantation and somite formation, complete penetrance ( J:148696 )

• no mice are present at E6.5

embryo

abnormal blastocyst morphology ( J:148696 )

• 72% of blastocysts cultured for 5 to 7 days exhibit overgrowth of the inner cell mass and giant trophoblasts compared with wild-type blastocysts

• blastocysts do not survive 8 days as do wild-type blastocysts

• of 2 recovered blastocysts, one hatched then displayed abrupt disintegration and fragmentation of the cell mass after attaching and outgrowing for one day while the other failed to attach

Allelic Composition	Tpt1^tm1Kefu/Tpt1^tm1Kefu
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpt1^tm1Kefu mutation (0 available); any Tpt1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:148696 )

• no mice are alive at 4 to 6 weeks of age

Allelic Composition	Tpt1^tm1Kefu/Tpt1⁺
Genetic Background	either: 129S6/SvEvTac-Tpt1^tm1Kefu or B6.129S6-Tpt1^tm1Kefu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpt1^tm1Kefu mutation (0 available); any Tpt1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased sensitivity to induced cell death ( J:148696 )

• mouse embryonic fibroblasts challenged with TNF-alpha, 5-fluorouracil, or thapsigargin exhibit increased apoptosis compared with similarly treated wild-type cells

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