Tpt1^tm1Kefu
Targeted Allele Detail

Summary

• Symbol: Tpt1^tm1Kefu
• Name: tumor protein, translationally-controlled 1; targeted mutation 1, Ken Fujise
• MGI ID: MGI:3846761
• Synonyms: fortilin^-
• Gene: Tpt1 Location: Chr14:76082472-76085743 bp, + strand Genetic Position: Chr14, 40.29 cM
• Alliance: Tpt1^tm1Kefu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148696
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 through 5 was replaced with a lacZ gene and neo cassette. Reduced protein expression was confirmed in heterozygous mouse embryonic fibroblasts by western blot analysis. (J:148696)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpt1 Mutation: 10 strains or lines available

References

• Original: J:148696 Koide Y, et al., Embryonic lethality of fortilin-null mutant mice by BMP-pathway overactivation. Biochim Biophys Acta. 2009 May;1790(5):326-38
• All: 2 reference(s)