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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smn1tm6(SMN2)Mrph
targeted mutation 6, Andrew Murphy
MGI:3846546
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Smn1tm6(SMN2)Mrph/Smn1tm6(SMN2)Mrph involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:5441045
ht2
Smn1tm2Mrph/Smn1tm6(SMN2)Mrph involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:5440975
ht3
Smn1tm4(SMN2)Mrph/Smn1tm6(SMN2)Mrph involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:5440977
ht4
Smn1tm5(Smn1/SMN2)Mrph/Smn1tm6(SMN2)Mrph involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:5441042


Genotype
MGI:5441045
hm1
Allelic
Composition
Smn1tm6(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm6(SMN2)Mrph mutation (3 available); any Smn1 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and necrosis is not observed




Genotype
MGI:5440975
ht2
Allelic
Composition
Smn1tm2Mrph/Smn1tm6(SMN2)Mrph
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm2Mrph mutation (3 available); any Smn1 mutation (86 available)
Smn1tm6(SMN2)Mrph mutation (3 available); any Smn1 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• onset of tail necrosis (tail swelling and shortening) occurs at 4 weeks of age

integument
• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears

cellular
• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears
• onset of tail necrosis (tail swelling and shortening) occurs at 4 weeks of age




Genotype
MGI:5440977
ht3
Allelic
Composition
Smn1tm4(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm4(SMN2)Mrph mutation (3 available); any Smn1 mutation (86 available)
Smn1tm6(SMN2)Mrph mutation (3 available); any Smn1 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• onset of tail necrosis (tail swelling and shortening) occurs at 4 weeks of age

integument
• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears

cellular
• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears
• onset of tail necrosis (tail swelling and shortening) occurs at 4 weeks of age




Genotype
MGI:5441042
ht4
Allelic
Composition
Smn1tm5(Smn1/SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm5(Smn1/SMN2)Mrph mutation (4 available); any Smn1 mutation (86 available)
Smn1tm6(SMN2)Mrph mutation (3 available); any Smn1 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• onset of tail necrosis (tail swelling and shortening) occurs at 6 weeks of age

integument
• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears

cellular
• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears
• onset of tail necrosis (tail swelling and shortening) occurs at 6 weeks of age





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory