Smn1^tm2Mrph
Targeted Allele Detail

Summary

• Symbol: Smn1^tm2Mrph
• Name: survival motor neuron 1; targeted mutation 2, Andrew Murphy
• MGI ID: MGI:3794065
• Synonyms: Smn1^KI, Smn1^KO, Smn1^lacZ, Smn allele A
• Gene: Smn1 Location: Chr13:100261360-100274198 bp, + strand Genetic Position: Chr13, 52.99 cM, cytoband D1/D2.1
• Alliance: Smn1^tm2Mrph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135422
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 8 of the mouse Smn1 (survival motor neuron 1) gene were replaced with lacZ and an FRT site remaining from the deletion of a selection marker. (J:135422)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Smn1 Mutation: 86 strains or lines available

References

• Original: J:135422 Murphy A (Regeneron Pharmaceuticals, Inc.), Smn1 deletion with lacZ knock in. Personal Communication. 2008
• All: 3 reference(s)