All Phenotypes Smn1<tm2Mrph> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smn1^tm2Mrph
targeted mutation 2, Andrew Murphy
MGI:3794065

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smn1^tm2Mrph/Smn1^tm2Mrph	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac	MGI:5440966
hm2	Smn1^tm2Mrph/Smn1^tm2Mrph	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:3794209
ht3	Smn1^tm2Mrph/Smn1^{tm4(SMN2)Mrph}	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac	MGI:5440967
ht4	Smn1^tm2Mrph/Smn1^{tm5(Smn1/SMN2)Mrph}	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac	MGI:5440968
ht5	Smn1^tm2Mrph/Smn1^{tm6(SMN2)Mrph}	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac	MGI:5440975

Allelic Composition	Smn1^tm2Mrph/Smn1^tm2Mrph
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1^tm2Mrph mutation (3 available); any Smn1 mutation (86 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:186987 )

• homozygotes are embryonic lethal

Allelic Composition	Smn1^tm2Mrph/Smn1^tm2Mrph
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1^tm2Mrph mutation (3 available); any Smn1 mutation (86 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:135422 )

• homozygotes die during development

Allelic Composition	Smn1^tm2Mrph/Smn1^{tm4(SMN2)Mrph}
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1^tm2Mrph mutation (3 available); any Smn1 mutation (86 available)
Smn1^{tm4(SMN2)Mrph} mutation (3 available); any Smn1 mutation (86 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:186987 )

• embryonic lethal

Allelic Composition	Smn1^tm2Mrph/Smn1^{tm5(Smn1/SMN2)Mrph}
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1^tm2Mrph mutation (3 available); any Smn1 mutation (86 available)
Smn1^{tm5(Smn1/SMN2)Mrph} mutation (4 available); any Smn1 mutation (86 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:186987 )

• embryonic lethal

Allelic Composition	Smn1^tm2Mrph/Smn1^{tm6(SMN2)Mrph}
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1^tm2Mrph mutation (3 available); any Smn1 mutation (86 available)
Smn1^{tm6(SMN2)Mrph} mutation (3 available); any Smn1 mutation (86 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

tail necrosis ( J:186987 )

• onset of tail necrosis (tail swelling and shortening) occurs at 4 weeks of age

integument

epidermal necrosis ( J:186987 )

• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears

cellular

epidermal necrosis ( J:186987 )

• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears

tail necrosis ( J:186987 )

• onset of tail necrosis (tail swelling and shortening) occurs at 4 weeks of age

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