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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CRP-TAg)60-3Urt
transgene insertion 60-3, Ulrich Ruther
MGI:3845887
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rr28tm1Tilg/Rr28+
Tg(CRP-TAg)60-3Urt/0 		involves: 129S1/Sv * C57BL/6 * SJL MGI:3845889
cx2
 		H19tm1Tilg/H19+
Tg(CRP-TAg)60-3Urt/0 		involves: 129S/SvEv * BALB/c * C57BL/6 * SJL MGI:3845888


Genotype
MGI:3845889
cx1
Allelic
Composition		 Rr28tm1Tilg/Rr28+
Tg(CRP-TAg)60-3Urt/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased liver tumor incidence ( J:138826 )
• 35% of male mice with the maternally inherited H19tm2Tilg allele develop liver tumors larger than 3 mm by 120 days compared to 20% of mice only expressing Tg(CRP-TAg)60-3Urt
• between 120 and 134 days, 48% of male mice with the maternally inherited H19tm2Tilg allele develop liver tumors compared to 30% of mice only expressing Tg(CRP-TAg)60-3Urt

liver/biliary system
increased liver tumor incidence ( J:138826 )
• 35% of male mice with the maternally inherited H19tm2Tilg allele develop liver tumors larger than 3 mm by 120 days compared to 20% of mice only expressing Tg(CRP-TAg)60-3Urt
• between 120 and 134 days, 48% of male mice with the maternally inherited H19tm2Tilg allele develop liver tumors compared to 30% of mice only expressing Tg(CRP-TAg)60-3Urt




Genotype
MGI:3845888
cx2
Allelic
Composition		 H19tm1Tilg/H19+
Tg(CRP-TAg)60-3Urt/0
Genetic
Background		 involves: 129S/SvEv * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19tm1Tilg mutation (1 available); any H19 mutation (12 available)
Tg(CRP-TAg)60-3Urt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased liver tumor incidence ( J:90036 )
• by 6 months mice with paternal inheritance of H19tm1Lda develop liver tumors unlike in wild-type mice

mortality/aging
mortality/aging ( J:90036 )
N
• mice with paternal inheritance of H19tm1Lda live longer than those expressing only Tg(CRP-TAg)60-3Urt

neoplasm
increased liver tumor incidence ( J:90036 )
• by 6 months mice with paternal inheritance of H19tm1Lda develop liver tumors unlike in wild-type mice
decreased tumor incidence ( J:90036 )
• when H19tm1Lda is inherited paternally, mice display a more than 3 week delay in spontaneous tumorigenesis and subsequent mortality associated with Tg(CRP-TAg)60-3Urt expression




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory