Analysis Tools
mortality/aging
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• mice are born with a two-fold lower frequency than expected from a normal Mendelian ratio
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behavior/neurological
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• mice show markedly increased freezing behaviour as evaluated by the context-dependent and tone-dependent fear conditioning models
• mice also have increased freezing response to short term context-dependent fear conditions
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growth/size/body
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• male and female mice are about 25% smaller than controls
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nervous system
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• the number of presynaptic terminals of functional synapses is significantly increased in the CA1 striatum radiatum
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• the density of dendritic spines along dentate gyrus granule cells is markedly increased
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• the density of dendritic spines along individual dendrites of hippocampal CA1 pyramidal neurons is markedly increased
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• robust LTP is readily induced by one train of high frequency stimulation in CA1 neurons whereas wild-type mice require two trains of stimulation
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reproductive system
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• fertility is compromised in these mice
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