All Phenotypes Zfp871<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zfp871⁺
wild type
MGI:3844875

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Zfp871^{tm1a(EUCOMM)Wtsi}/Zfp871⁺	C57BL/6N-Zfp871^{tm1a(EUCOMM)Wtsi}/BayMmucd	MGI:7517194
ht2	Zfp871^{tm1b(EUCOMM)Wtsi}/Zfp871⁺	C57BL/6N-Zfp871^{tm1b(EUCOMM)Wtsi}/Bay	MGI:6461832

Allelic Composition	Zfp871^{tm1a(EUCOMM)Wtsi}/Zfp871⁺
Genetic Background	C57BL/6N-Zfp871^{tm1a(EUCOMM)Wtsi}/BayMmucd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp871^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Zfp871 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:317166 )

N	• not prone to spontaneous tumors but do show a shift in tumor spectrum

decreased lymphoma incidence ( J:317166 )

• no incidence of T-cell lymphoma compared to 3.7% in wild-type mice

increased B cell derived lymphoma incidence ( J:317166 )

• slightly increased,16.7% incidence compared to 11.8% in wild-type mice

liver/biliary system

liver inflammation ( J:317166 )

• steatohepatitis in 50% of mice compared to 6% in wild-type mice

hepatic steatosis ( J:317166 )

• steatohepatitis in 50% of mice compared to 6% in wild-type mice

endocrine/exocrine glands

thymus hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

hematopoietic system

thymus hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

spleen hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

growth/size/body

decreased body size ( J:317166 )

spleen hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

immune system

thymus hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

spleen hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

liver inflammation ( J:317166 )

• steatohepatitis in 50% of mice compared to 6% in wild-type mice

mortality/aging

premature death ( J:317166 )

• median survival time (89.3 weeks) is decreased compared to wild-type controls (117 weeks)

Allelic Composition	Zfp871^{tm1b(EUCOMM)Wtsi}/Zfp871⁺
Genetic Background	C57BL/6N-Zfp871^{tm1b(EUCOMM)Wtsi}/Bay
Cell Lines	EPD0801_4_B07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp871^{tm1b(EUCOMM)Wtsi} mutation (0 available); any Zfp871 mutation (29 available)

Data Sources

IMPC Data for Zfp871

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

IMPC - BCM

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

IMPC - BCM

vision/eye

abnormal retina blood vessel morphology ( J:211773 )

IMPC - BCM

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - BCM

decreased total retina thickness ( J:211773 )

IMPC - BCM

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/28/2026 MGI 6.24