About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Khdc3tm1Dean
targeted mutation 1, Jurrien Dean
MGI:3844604
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Khdc3tm1Dean/Khdc3tm1Dean involves: 129/Sv * C57BL/6 MGI:3844607


Genotype
MGI:3844607
hm1
Allelic
Composition
Khdc3tm1Dean/Khdc3tm1Dean
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Khdc3tm1Dean mutation (1 available); any Khdc3 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Impaired preimplantation development of Khdc3tm1Dean/Khdc3tm1Dean embryos

reproductive system
N
• no defects in oogenesis, ovulation or fertilization are detected and the subcortical maternal complex persists
• during a 6 month span females produced from 0 to 5 litters and the time from mating to delivery was increased to about 30 days (range 20 - 120 days) cmpared to about 20 days in controls
• litter size is reduced when females are crossed to homozygous, heterozygous, or wild-type males

cellular
• significantly fewer embryos reach the morula or blastocyst stage when the mother is homozygous null
• when the mother is homozygous null, embryonic development is delayed in some embryos as a result of a prolongation of the G2 phase of cell division and many of these delayed embryos display aneuploidy
• delayed embryos display spindle abnormalities and defects in spindle assembly checkpoint function





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
06/12/2024
MGI 6.13
The Jackson Laboratory