Phenotypes associated with this allele

• Allele Symbol: Khdc3^tm1Dean
• Allele Name: targeted mutation 1, Jurrien Dean
• Allele ID: MGI:3844604
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Khdc3^tm1Dean/Khdc3^tm1Dean	involves: 129/Sv * C57BL/6	MGI:3844607

Genotype
MGI:3844607

hm1

• Allelic Composition: Khdc3^tm1Dean/Khdc3^tm1Dean
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Impaired preimplantation development of Khdc3^tm1Dean/Khdc3^tm1Dean embryos

reproductive system

reproductive system phenotype ( J:148330 )

N • no defects in oogenesis, ovulation or fertilization are detected and the subcortical maternal complex persists

reduced female fertility ( J:148330 )

♀ • during a 6 month span females produced from 0 to 5 litters and the time from mating to delivery was increased to about 30 days (range 20 - 120 days) cmpared to about 20 days in controls

decreased litter size ( J:148330 )

• litter size is reduced when females are crossed to homozygous, heterozygous, or wild-type males

cellular

maternal effect ( J:148330 )

• significantly fewer embryos reach the morula or blastocyst stage when the mother is homozygous null

• when the mother is homozygous null, embryonic development is delayed in some embryos as a result of a prolongation of the G2 phase of cell division and many of these delayed embryos display aneuploidy

• delayed embryos display spindle abnormalities and defects in spindle assembly checkpoint function