About   Help   FAQ
Khdc3tm1Dean
Targeted Allele Detail
Summary
Symbol: Khdc3tm1Dean
Name: KH domain containing 3, subcortical maternal complex member; targeted mutation 1, Jurrien Dean
MGI ID: MGI:3844604
Synonyms: Filiatm
Gene: Khdc3  Location: Chr9:73009118-73011720 bp, + strand  Genetic Position: Chr9, 40.08 cM
Alliance: Khdc3tm1Dean page
Impaired preimplantation development of Khdc3tm1Dean/Khdc3tm1Dean embryos

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148330
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first 2 exons including the transcription and translation start sites and part of the 5' UTR were replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of protein expression in ovaries from homozygous mice. (J:148330)
Generation of the Khdc3tm1Dean allele
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Khdc3 Mutation:  15 strains or lines available
References
Original:  J:148330 Zheng P, et al., Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7473-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/28/2024
MGI 6.13
The Jackson Laboratory