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Targeted Allele Detail
Symbol: Khdc3tm1Dean
Name: KH domain containing 3, subcortical maternal complex member; targeted mutation 1, Jurrien Dean
MGI ID: MGI:3844604
Synonyms: Filiatm
Gene: Khdc3  Location: Chr9:73009118-73011720 bp, + strand  Genetic Position: Chr9, 40.08 cM
Alliance: Khdc3tm1Dean page
Impaired preimplantation development of Khdc3tm1Dean/Khdc3tm1Dean embryos

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:148330
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first 2 exons including the transcription and translation start sites and part of the 5' UTR were replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of protein expression in ovaries from homozygous mice. (J:148330)
Generation of the Khdc3tm1Dean allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Khdc3 Mutation:  15 strains or lines available
Original:  J:148330 Zheng P, et al., Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7473-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory