Analysis Tools
homeostasis/metabolism
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• when mice are fed a high fat diet fasting glucose levels are increased compared to diet matched wild-type controls
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• when mice are fed a high fat diet fasting insulin levels are increased compared to diet matched wild-type controls
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• on a high fat diet hepatic gluconeogenesis is enhanced compared to diet matched controls
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• more severe insulin resistance compared to diet matched wild-type controls
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• increase in liver triacylglycerol levels in mice on a high fat diet compared to diet matched wild-type controls
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muscle
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• decrease in glucose uptake in skeletal muscles in mice on a high fat diet compared to diet matched wild-type controls
• in isolated skeletal muscle cells from mice on a high fat diet insulin stimulated glucose uptake capacity is significantly decreased compared to diet matched wild-type controls
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growth/size/body
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• on standard chow or high fat diets no differences in body weight are detected compared to diet matched wild-type mice
• the basic phenotype for these mice is stated to be similar to that of mice homozygous for Cpt1ctm1Mdln
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cellular
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• decrease in glucose uptake in skeletal muscles in mice on a high fat diet compared to diet matched wild-type controls
• in isolated skeletal muscle cells from mice on a high fat diet insulin stimulated glucose uptake capacity is significantly decreased compared to diet matched wild-type controls
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