Cpt1c^tm1Dhwu
Targeted Allele Detail

Summary

• Symbol: Cpt1c^tm1Dhwu
• Name: carnitine palmitoyltransferase 1c; targeted mutation 1, Donghai Wu
• MGI ID: MGI:3844092
• Gene: Cpt1c Location: Chr7:44608796-44624275 bp, - strand Genetic Position: Chr7, 29.07 cM, cytoband B2
• Alliance: Cpt1c^tm1Dhwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148205
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.3 kb fragment including exon 3 was replaced with a pgk-neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in the brains of homozygous mice. (J:148205)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpt1c Mutation: 42 strains or lines available

References

• Original: J:148205 Gao XF, et al., Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake. Diabetologia. 2009 May;52(5):912-20
• All: 1 reference(s)