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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lattm1.1Wz
targeted mutation 1.1, Weiguo Zhang
MGI:3843455
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Lattm1Les/Lattm1.1Wz involves: C57BL/6 MGI:3843486
cn2
 		Lattm1Les/Lattm1.1Wz
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:3843484


Genotype
MGI:3843486
ht1
Allelic
Composition		 Lattm1Les/Lattm1.1Wz
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1.1Wz mutation (0 available); any Lat mutation (10 available)
Lattm1Les mutation (0 available); any Lat mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal effector T cell morphology ( J:147946 )
• the percentage of mature T cells in the periphery is lower than in wild-type mice
• however, thymocyte development is otherwise normal

immune system
abnormal effector T cell morphology ( J:147946 )
• the percentage of mature T cells in the periphery is lower than in wild-type mice
• however, thymocyte development is otherwise normal




Genotype
MGI:3843484
cn2
Allelic
Composition		 Lattm1Les/Lattm1.1Wz
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1.1Wz mutation (0 available); any Lat mutation (10 available)
Lattm1Les mutation (0 available); any Lat mutation (10 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:147946 )
• based on marker expression, thymocyte positive selection is impaired and single positive thymocyte development is blocked unlike in wild-type mice
increased double-positive T cell number ( J:147946 )
• the percentage of double positive thymocytes is slightly increased compared to in wild-type mice
• however, the absolute numbers of double positive thymocytes are normal
increased gamma-delta T cell number ( J:147946 )
• the percentage of gamma delta T cells is increased compared to in wild-type mice
abnormal effector T cell morphology ( J:147946 )
• the number of mature T cells is decreased compared to in wild-type mice
• few mature T cells are GFP+
decreased CD4-positive, alpha-beta T cell number ( J:147946 )
• the number of CD4+ T cells is decreased 10-fold compared to in wild-type mice
• the CD4+ T cells that remain are GFP-
decreased CD8-positive, alpha-beta T cell number ( J:147946 )
• the number of CD8+ T cells is decreased 20-fold compared to in wild-type mice
• the CD8+ T cells that remain are GFP-
• however, the number of immature single positive cells is normal
abnormal T cell physiology ( J:147946 )
• TCR-mediated calcium fluxes are abrogated unlike in wild-type mice

hematopoietic system
abnormal T cell differentiation ( J:147946 )
• based on marker expression, thymocyte positive selection is impaired and single positive thymocyte development is blocked unlike in wild-type mice
increased double-positive T cell number ( J:147946 )
• the percentage of double positive thymocytes is slightly increased compared to in wild-type mice
• however, the absolute numbers of double positive thymocytes are normal
increased gamma-delta T cell number ( J:147946 )
• the percentage of gamma delta T cells is increased compared to in wild-type mice
abnormal effector T cell morphology ( J:147946 )
• the number of mature T cells is decreased compared to in wild-type mice
• few mature T cells are GFP+
decreased CD4-positive, alpha-beta T cell number ( J:147946 )
• the number of CD4+ T cells is decreased 10-fold compared to in wild-type mice
• the CD4+ T cells that remain are GFP-
decreased CD8-positive, alpha-beta T cell number ( J:147946 )
• the number of CD8+ T cells is decreased 20-fold compared to in wild-type mice
• the CD8+ T cells that remain are GFP-
• however, the number of immature single positive cells is normal
abnormal T cell physiology ( J:147946 )
• TCR-mediated calcium fluxes are abrogated unlike in wild-type mice

endocrine/exocrine glands




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory