Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1.1Wz mutation
(0 available);
any
Lat mutation
(9 available)
Lattm1Les mutation
(0 available);
any
Lat mutation
(9 available)
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hematopoietic system
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• the percentage of mature T cells in the periphery is lower than in wild-type mice
• however, thymocyte development is otherwise normal
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immune system
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• the percentage of mature T cells in the periphery is lower than in wild-type mice
• however, thymocyte development is otherwise normal
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1.1Wz mutation
(0 available);
any
Lat mutation
(9 available)
Lattm1Les mutation
(0 available);
any
Lat mutation
(9 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• based on marker expression, thymocyte positive selection is impaired and single positive thymocyte development is blocked unlike in wild-type mice
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• the percentage of double positive thymocytes is slightly increased compared to in wild-type mice
• however, the absolute numbers of double positive thymocytes are normal
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• the percentage of gamma delta T cells is increased compared to in wild-type mice
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• the number of mature T cells is decreased compared to in wild-type mice
• few mature T cells are GFP+
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• the number of CD4+ T cells is decreased 10-fold compared to in wild-type mice
• the CD4+ T cells that remain are GFP-
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• the number of CD8+ T cells is decreased 20-fold compared to in wild-type mice
• the CD8+ T cells that remain are GFP-
• however, the number of immature single positive cells is normal
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• TCR-mediated calcium fluxes are abrogated unlike in wild-type mice
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hematopoietic system
|
|
• based on marker expression, thymocyte positive selection is impaired and single positive thymocyte development is blocked unlike in wild-type mice
|
|
|
• however, the absolute numbers of double positive thymocytes are normal
• the percentage of double positive thymocytes is slightly increased compared to in wild-type mice
|
|
|
• the percentage of gamma delta T cells is increased compared to in wild-type mice
|
|
|
• the number of mature T cells is decreased compared to in wild-type mice
• few mature T cells are GFP+
|
|
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• the number of CD4+ T cells is decreased 10-fold compared to in wild-type mice
• the CD4+ T cells that remain are GFP-
|
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• the number of CD8+ T cells is decreased 20-fold compared to in wild-type mice
• the CD8+ T cells that remain are GFP-
• however, the number of immature single positive cells is normal
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• TCR-mediated calcium fluxes are abrogated unlike in wild-type mice
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endocrine/exocrine glands
Analysis Tools