All Phenotypes Lcp2<tm5(Lat/Lcp2)Gak> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak}	involves: 129S1/Sv * 129X1/SvJ	MGI:3842653
cx2	Lat^tm1Les/Lat^tm1Les Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak}	involves: 129S1/Sv * 129X1/SvJ	MGI:3842654

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:147721 )

• cellularity of the thymus is 40% of wild-type reflecting diminished double-positive and single-positive thymocyte populations

abnormal thymocyte activation ( J:147721 )

• calcium flux upon activation of double-positive thymocytes is severely diminished compared to controls

decreased double-positive T cell number ( J:147721 )

• number of double-positive thymocytes is reduced by about 40%

arrested T cell differentiation ( J:147721 )

• thymocytes are arrested at the double-positive stage

• the few single-positive CD8⁺ T cells present express heat-stable antigen and are considered an immature, transient population

decreased single-positive T cell number ( J:147721 )

• mature single positive thymocytes are absent

hematopoietic system

thymus hypoplasia ( J:147721 )

• cellularity of the thymus is 40% of wild-type reflecting diminished double-positive and single-positive thymocyte populations

abnormal thymocyte activation ( J:147721 )

• calcium flux upon activation of double-positive thymocytes is severely diminished compared to controls

decreased double-positive T cell number ( J:147721 )

• number of double-positive thymocytes is reduced by about 40%

arrested T cell differentiation ( J:147721 )

• thymocytes are arrested at the double-positive stage

• the few single-positive CD8⁺ T cells present express heat-stable antigen and are considered an immature, transient population

decreased single-positive T cell number ( J:147721 )

• mature single positive thymocytes are absent

endocrine/exocrine glands

thymus hypoplasia ( J:147721 )

• cellularity of the thymus is 40% of wild-type reflecting diminished double-positive and single-positive thymocyte populations

abnormal thymocyte activation ( J:147721 )

• calcium flux upon activation of double-positive thymocytes is severely diminished compared to controls

Allelic Composition	Lat^tm1Les/Lat^tm1Les Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat^tm1Les mutation (0 available); any Lat mutation (9 available)
Lcp2^{tm5(Lat/Lcp2)Gak} mutation (0 available); any Lcp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-positive T cell number ( J:147721 )

• double-positive thymocytes are absent in these mice

arrested T cell differentiation ( J:147721 )

• thymocytes are arrested at the DN3 stage

hematopoietic system

decreased double-positive T cell number ( J:147721 )

• double-positive thymocytes are absent in these mice

arrested T cell differentiation ( J:147721 )

• thymocytes are arrested at the DN3 stage

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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