All Phenotypes Use1<tm1.2Aha> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Use1^tm1.2Aha
targeted mutation 1.2, Akihiro Harada
MGI:3842571

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Use1^tm1.2Aha/Use1^tm1.2Aha	involves: BALB/cJ * C57BL/6 * SJL	MGI:3842579
cn2	Use1^tm1.1Aha/Use1^tm1.2Aha	involves: BALB/cJ * C57BL/6 * SJL	MGI:3842578
cn3	Use1^tm1.1Aha/Use1^tm1.2Aha Tg(Pcp2-cre)2Mpin/0	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:3842577

Allelic Composition	Use1^tm1.2Aha/Use1^tm1.2Aha
Genetic Background	involves: BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Use1^tm1.2Aha mutation (1 available); any Use1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:147771 )

• die before E8.5

Allelic Composition	Use1^tm1.1Aha/Use1^tm1.2Aha
Genetic Background	involves: BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Use1^tm1.1Aha mutation (1 available); any Use1 mutation (18 available)
Use1^tm1.2Aha mutation (1 available); any Use1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal endoplasmic reticulum morphology ( J:147771 )

• increase in the percentage of MEF cells with vacuolated ER structures and decrease in the percentage of cells with vesiculated ER structures with time following adenoviral cre treatment

increased fibroblast apoptosis ( J:147771 )

• in MEFs after adenoviral cre treatment

increased endoplasmic reticulum stress ( J:147771 )

• expression analysis indicates increased endoplasmic reticulum stress following adenoviral cre treatment

• protein transport from the endoplasmic reticulum to the Golgi complex is impaired

Allelic Composition	Use1^tm1.1Aha/Use1^tm1.2Aha Tg(Pcp2-cre)2Mpin/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pcp2-cre)2Mpin mutation (1 available)
Use1^tm1.1Aha mutation (1 available); any Use1 mutation (18 available)
Use1^tm1.2Aha mutation (1 available); any Use1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:147771 )

• display cerebellar ataxia after 10 weeks of age

abnormal gait ( J:147771 )

• after 10 weeks of age

nervous system

decreased Purkinje cell number ( J:147771 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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