All Phenotypes Rbx1<Gt(XB674)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rbx1^Gt(XB674)Byg
gene trap XB674, BayGenomics
MGI:3842436

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbx1^Gt(XB674)Byg/Rbx1^Gt(XB674)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3842437
ht2	Rbx1^Gt(XB674)Byg/Rbx1⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3842438
cx3	Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Rbx1^Gt(XB674)Byg/Rbx1^Gt(XB674)Byg	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	MGI:3842439

Allelic Composition	Rbx1^Gt(XB674)Byg/Rbx1^Gt(XB674)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbx1^Gt(XB674)Byg mutation (0 available); any Rbx1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

A Rbx1^Gt(XB674)Byg/Rbx1^Gt(XB674)Byg embryo at E6.5 is viable but smaller than wild-type or heterozygous embryos

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:147759 )

• die between E6.5 and E7.5

cellular

increased embryonic tissue cell apoptosis ( J:147759 )

• slight increase in apoptosis in embryos at E6.5

decreased cell proliferation ( J:147759 )

• dramatic reduction in cell proliferation in embryos at E6.5

• unable to establish ES cell lines from E3.5 embryos

embryo

increased embryonic tissue cell apoptosis ( J:147759 )

• slight increase in apoptosis in embryos at E6.5

abnormal preimplantation embryo development ( J:147759 )

• general hypocellularity in embryos at E6.5

decreased embryo size ( J:147759 )

• at E6.5

growth/size/body

decreased embryo size ( J:147759 )

• at E6.5

Allelic Composition	Rbx1^Gt(XB674)Byg/Rbx1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbx1^Gt(XB674)Byg mutation (0 available); any Rbx1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:147759 )

• 24 h after release from serum starvation most MEF cells are still arrested at the G1 phase of the cell cycle unlike in wild-type controls where most cells have entered S phase

decreased cell proliferation ( J:147759 )

• MEFs show a much slower growth rate compared to wild-type controls

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Rbx1^Gt(XB674)Byg/Rbx1^Gt(XB674)Byg
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)
Rbx1^Gt(XB674)Byg mutation (0 available); any Rbx1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:147759 )

• die between E9.5 and E10.5

cellular

cellular phenotype ( J:147759 )

N	• unlike in Rbx1^Gt(XB674)Byg single homozygous mice, double homozygous embryos show normal cell proliferation at E6.5

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