|
Allele Symbol Allele Name Allele ID |
Pou4f2tm2.1Nat targeted mutation 2.1, Jeremy Nathans MGI:3842365 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• medial regions of the suprachiasmatic nucleus are not innervated at all
|
|
• the suprachiasmatic nucleus (SCN) is sparsely innervated by Pou4f2-positive ipRGCs (intrinsically photosensitive retinal ganglion cells)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• with injection of 500 ug tamoxifen intraperitoneally at P14, medial regions of the suprachiasmatic nucleus are not innervated at all
|
|
• with injection of 500 ug tamoxifen intraperitoneally at P14, suprachiasmatic nucleus (SCN) is sparsely innervated by Pou4f2-positive ipRGCs (intrinsically photosensitive retinal ganglion cells)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• retinal ganglion cells (RGC) have larger surface area and thick arbors
• some RGC axons follow aberrant trajectories, bifurcate within the retina or give rise to dendrite-like branches that ramify within the inner plexiform data
• a small percentage of RGC lack axons
• RGC cell body is more likely to reside in the inner nuclear layer (INL) than in the ganglion cell layer (GCL)
• the ratio of INL:GCL cell bodies is 178:105 compared with 9:147 for controls
• these misplaced RGC display morphological characteristics of glycinergic amacrine cells
• projections from the RGC are deficient to the olivary pretectal nucleus, the pretectal area and adjacent nucleus of the optic tract
• projections to the lateral and medial terminal nuclei are eliminated and the accessory optic tract is missing
|
|
• 70% of retinal ganglion cells are not present
|
|
• large decrements in RGC projections occur to the nucleus adjacent to the optic tract compared to controls
• the accessory optic tract is missing
• numerous neurites emerge at P4 from the optic tract and penetrate nearby nontarget areas
|
|
• large decrements in RGC projections occur to this part of the brain compared to controls
|
|
• large decrements in RGC projections occur to this part of the brain compared to controls
|
|
• retinal ganglion cells (RGC) have larger surface area and thick arbors
• some RGC axons follow aberrant trajectories, bifurcate within the retina or give rise to dendrite-like branches that ramify within the inner plexiform data
• a small percentage of RGC lack axons
• RGC cell body is more likely to reside in the inner nuclear layer (INL) than in the ganglion cell layer (GCL)
• the ratio of INL:GCL cell bodies is 178:105 compared with 9:147 for controls
• these misplaced RGC display morphological characteristics of glycinergic amacrine cells
• projections from the RGC are deficient to the olivary pretectal nucleus, the pretectal area and adjacent nucleus of the optic tract
• projections to the lateral and medial terminal nuclei are eliminated and the accessory optic tract is missing
|
|
• 70% of retinal ganglion cells are not present
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools