Phenotypes associated with this allele

• Allele Symbol: Olig3^tm1(cre)Ynka
• Allele Name: targeted mutation 1, Yasushi Nakagawa
• Allele ID: MGI:3841452
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Smo/EYFP)Amc/Gt(ROSA)26Sor^+ Olig3^tm1(cre)Ynka/Olig3^+	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:3844928
cn2	Olig3^tm1(cre)Ynka/Olig3^+ Smo^tm2Amc/Smo^tm2Amc	involves: 129X1/SvJ * C57BL/6J	MGI:3844943

Genotype
MGI:3844928

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺; Olig3^tm1(cre)Ynka/Olig3⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:147427 )

• partial; some pups survive postnatally

nervous system

nervous system phenotype ( J:147427 )

N • brains are morphologically indistinguishable from controls

abnormal thalamus morphology ( J:147427 )

• expansion of the expression domain of the orphan receptor ROR alpha indicates that the the ventral posterior nucleus (VP) is increased in size

• in E18.5 brains, molecular marker analysis indicates that the entire postmitotic thalamus exhibits rostroventral identity

abnormal lateral geniculate nucleus morphology ( J:147427 )

• based on thalamic labeling by cholera toxin B subunit injection, the volume of the dorsal lateral geniculate nucleus (dLG) is increased more than 3-fold compared to control neonatal animals; expansion of the expression domain of the orphan receptor ROR alpha indicates that the dLG is increased in size

Genotype
MGI:3844943

cn2

• Allelic Composition: Olig3^tm1(cre)Ynka/Olig3⁺; Smo^tm2Amc/Smo^tm2Amc
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

nervous system

abnormal thalamus morphology ( J:147427 )

• based on molecular marker expression analysis, the intergeniculate leaflet (IGL) nucleus is dramatically reduced in size and cell number at E17.5