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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gbx2tm1.1(cre/ERT2)Jyhl
targeted mutation 1.1, James Y H Li
MGI:3840448
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1.1Mrt involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:3840449
cn2
 		Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1.1Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:3840450
cn3
 		Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:3840452


Genotype
MGI:3840449
ht1
Allelic
Composition		 Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1.1Mrt
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2tm1.1(cre/ERT2)Jyhl mutation (1 available); any Gbx2 mutation (27 available)
Gbx2tm1.1Mrt mutation (0 available); any Gbx2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
absent cerebellum ( J:147282 )
• at E18.5




Genotype
MGI:3840450
cn2
Allelic
Composition		 Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1.1Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2tm1.1(cre/ERT2)Jyhl mutation (1 available); any Gbx2 mutation (27 available)
Gbx2tm1.1Mrt mutation (0 available); any Gbx2 mutation (27 available)
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal telencephalon development ( J:147282 )
• at E14.5, cells expressing lacZ are found across the dorsal and posterior borders of the thalamus expanding into the epithalamus and pretectum
• ectopic lacZ expressing cells from the thalamus are mainly found in the lateral habenular nuclei and anterior part of the pretectum at E18.5
abnormal thalamus morphology ( J:147282 )
• at E10.5 the thalamus is smaller in the mediolateral dimension and larger in the ventrodorsal dimension
• thalamus morphology is severely disrupted after E14.5




Genotype
MGI:3840452
cn3
Allelic
Composition		 Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2tm1.1(cre/ERT2)Jyhl mutation (1 available); any Gbx2 mutation (27 available)
Gbx2tm1Mrt mutation (0 available); any Gbx2 mutation (27 available)
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal thalamus morphology ( J:147282 )
• following tamoxifen treatment mild defects in thalamus morphology are seen in some mutants with high levels of recombination but for the most part defects in establishment of dorsal and posterior thalamic boundaries seen in null mice are not seen
• this result and chimera experiments suggest that the function of Gbx2 is cell nonautonomous




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory