Gbx2^{tm1.1(cre/ERT2)Jyhl}
Targeted Allele Detail

Summary

• Symbol: Gbx2^{tm1.1(cre/ERT2)Jyhl}
• Name: gastrulation brain homeobox 2; targeted mutation 1.1, James Y H Li
• MGI ID: MGI:3840448
• Synonyms: Gbx2^CreER, Gbx2^{CreER-ires-eGFP}
• Gene: Gbx2 Location: Chr1:89855684-89858898 bp, - strand Genetic Position: Chr1, 45.06 cM, cytoband C5-E1
• Alliance: Gbx2^{tm1.1(cre/ERT2)Jyhl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147282
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gbx2^{tm1.1(cre/ERT2)Jyhl} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gbx2 (MGI:95668)

• Mutation details: A cre/ERT2-IRES-EGFP-frt flanked neo cassette was inserted into the 5' untranslated region via homologous recombination. The neo cassette was then removed by Flp mediated recombination. Expression patterns of cre/ERT2 transcripts and EGFP proteins match those of the endogenous protein. (J:147282)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gbx2 (mouse) Summary of all recombinase alleles driven by Gbx2. Alliance mouse Gbx2 gene page

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gbx2 Mutation: 27 strains or lines available

References

• Original: J:147282 Chen L, et al., Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus. Development. 2009 Apr;136(8):1317-26
• All: 35 reference(s)