All Phenotypes Myod1<tm2.1(icre)Glh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myod1^{tm2.1(icre)Glh}
targeted mutation 2.1, David J Goldhamer
MGI:3840216

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Abl1^tm1Gcos/Abl1⁺ Myf5^tm2Tajb/Myf5^tm2Tajb Myf6^tm1Tajb/Myf6^tm1Tajb Myod1^{tm2.1(icre)Glh}/Myod1⁺	involves: 129S * 129X1/SvJ * C57BL/6J	MGI:4939891
cn2	Chodl^em1Feyu/Chodl^em1Feyu Myod1^{tm2.1(icre)Glh}/Myod1⁺	involves: 129S6/SvEvTac * C57BL/6J	MGI:8402570
cn3	Acvr1^tm1Glh/Acvr1⁺ Myod1^{tm2.1(icre)Glh}/Myod1⁺	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:7278769

Allelic Composition	Abl1^tm1Gcos/Abl1⁺ Myf5^tm2Tajb/Myf5^tm2Tajb Myf6^tm1Tajb/Myf6^tm1Tajb Myod1^{tm2.1(icre)Glh}/Myod1⁺
Genetic Background	involves: 129S * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1^tm1Gcos mutation (0 available); any Abl1 mutation (94 available)
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (19 available)
Myf6^tm1Tajb mutation (0 available); any Myf6 mutation (18 available)
Myod1^{tm2.1(icre)Glh} mutation (1 available); any Myod1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal myogenesis ( J:168843 )

• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:168843 )

• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice

Allelic Composition	Chodl^em1Feyu/Chodl^em1Feyu Myod1^{tm2.1(icre)Glh}/Myod1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chodl^em1Feyu mutation (0 available); any Chodl mutation (27 available)
Myod1^{tm2.1(icre)Glh} mutation (1 available); any Myod1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:384967 )

N	• no abnormalities in muscle growth or muscle fiber composition

abnormal skeletal muscle morphology ( J:384967 )

• at P7 and P21, higher percentages of satellite cells are located outside the basal lamina compared to controls suggesting a defect in homing

decreased satellite cell number ( J:384967 )

• 52% reduction in the number of PAX7+ satellite cells per tibialis anterior area

• at 21 days post injury the number of satellite cells is reduced by 70%

• in aged mice there is a 37% reduction in the number of PAX7+ satellite cells compared to age matched controls

impaired skeletal muscle regeneration ( J:384967 )

• reduced muscle recovery rate following CTX-induced injury of tibialis anterior (TA) muscles at 21 days post injury

• however, at 7 days post injury ratio of injured to uninjured TA muscle mass is similar to controls

• at both 7 and 21 days post injury muscles contain smaller centrally nucleated myofibers and myofibers are smaller at 7 days post injury

• muscle recovery rate in aged mice is also reduced with fewer centrally nucleated myofibers in injured TA muscles at 5 days post infection

Allelic Composition	Acvr1^tm1Glh/Acvr1⁺ Myod1^{tm2.1(icre)Glh}/Myod1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1^tm1Glh mutation (0 available); any Acvr1 mutation (45 available)
Myod1^{tm2.1(icre)Glh} mutation (1 available); any Myod1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:257905 )

N	• pinch or cardiotoxin-mediated injury of the gastrocnemius or tibialis anterior hindlimb muscles of adults does not cause heterotopic ossification

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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