About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3r5tm1Lste
targeted mutation 1, Len Stephens
MGI:3840090
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pik3r5tm1Lste/Pik3r5tm1Lste involves: 129P2/OlaHsd MGI:5903755
hm2
 		Pik3r5tm1Lste/Pik3r5tm1Lste involves: 129P2/OlaHsd * C57BL/6 MGI:3840103


Genotype
MGI:5903755
hm1
Allelic
Composition		 Pik3r5tm1Lste/Pik3r5tm1Lste
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r5tm1Lste mutation (0 available); any Pik3r5 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil chemotaxis ( J:238900 )
• after thioglycollate injection

cellular
impaired neutrophil chemotaxis ( J:238900 )
• after thioglycollate injection

hematopoietic system
impaired neutrophil chemotaxis ( J:238900 )
• after thioglycollate injection




Genotype
MGI:3840103
hm2
Allelic
Composition		 Pik3r5tm1Lste/Pik3r5tm1Lste
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r5tm1Lste mutation (0 available); any Pik3r5 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil chemotaxis ( J:147259 )
• reduced chemotactic and chemokinetic response to fMLP, C5a, or MIP2
impaired neutrophil recruitment ( J:147259 )
• reduced recruitment to the peritoneum in thioglycollate induced peritonitis

cellular
impaired neutrophil chemotaxis ( J:147259 )
• reduced chemotactic and chemokinetic response to fMLP, C5a, or MIP2

hematopoietic system
impaired neutrophil chemotaxis ( J:147259 )
• reduced chemotactic and chemokinetic response to fMLP, C5a, or MIP2
impaired neutrophil recruitment ( J:147259 )
• reduced recruitment to the peritoneum in thioglycollate induced peritonitis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory