Phenotypes associated with this allele

• Allele Symbol: Sell^tm2Hyn
• Allele Name: targeted mutation 2, Richard Hynes
• Allele ID: MGI:3839975
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sell^tm2Hyn/Sell^tm2Hyn	involves: 129S2/SvPas * BALB/c	MGI:4354510
hm2	Sell^tm2Hyn/Sell^tm2Hyn	involves: 129S2/SvPas * C57BL/6	MGI:3840201
cx3	Cd44^tm2Kmz/Cd44^tm2Kmz Sell^tm2Hyn/Sell^tm2Hyn	involves: 129S2/SvPas * BALB/c * DBA/1	MGI:4354509

Genotype
MGI:4354510

hm1

• Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn
• Genetic Background: involves: 129S2/SvPas * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired leukocyte tethering or rolling ( J:114317 )

• less rolling leukocytes are observed in the postcapillary venules of inflamed ears 12 hours after immunization compared to controls

• velocity of these rolling leukocytes is greater than controls 1 hour after immunization

cellular

impaired leukocyte tethering or rolling ( J:114317 )

• less rolling leukocytes are observed in the postcapillary venules of inflamed ears 12 hours after immunization compared to controls

• velocity of these rolling leukocytes is greater than controls 1 hour after immunization

hematopoietic system

impaired leukocyte tethering or rolling ( J:114317 )

• less rolling leukocytes are observed in the postcapillary venules of inflamed ears 12 hours after immunization compared to controls

• velocity of these rolling leukocytes is greater than controls 1 hour after immunization

Genotype
MGI:3840201

hm2

• Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn
• Genetic Background: involves: 129S2/SvPas * C57BL/6

immune system

immune system phenotype ( J:106550 )

N • mutants and controls show similar neutrophil accumulation in sinusoids and parenchyma at 7 hours after galactosamine/bacterial endotoxin treatment

impaired leukocyte tethering or rolling ( J:57973 )

• there is a two-thirds decrease in the number of rolling leukocytes within the mesenteric venules of mice treated with TNF

• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules

• mean velocity of leukocytes is decreased

decreased monocyte cell number ( J:57973 )

• monocyte numbers are decreased by more than half in the blood

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2 hours after injection

hematopoietic system

impaired leukocyte tethering or rolling ( J:57973 )

• there is a two-thirds decrease in the number of rolling leukocytes within the mesenteric venules of mice treated with TNF

• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules

• mean velocity of leukocytes is decreased

decreased monocyte cell number ( J:57973 )

• monocyte numbers are decreased by more than half in the blood

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2 hours after injection

neoplasm

decreased metastatic potential ( J:106671 )

decreased tumor incidence ( J:106671 )

• poorer survival of tumor cells

liver/biliary system

liver/biliary system phenotype ( J:106550 )

N • liver injury including necrosis are similar between treated mutants and controls at 7 hours after treatment

cellular

impaired leukocyte tethering or rolling ( J:57973 )

• there is a two-thirds decrease in the number of rolling leukocytes within the mesenteric venules of mice treated with TNF

• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules

• mean velocity of leukocytes is decreased

Genotype
MGI:4354509

cx3

• Allelic Composition: Cd44^tm2Kmz/Cd44^tm2Kmz; Sell^tm2Hyn/Sell^tm2Hyn
• Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

immune system

abnormal leukocyte adhesion ( J:114317 )

• the number of adherent leukocytes observed in the postcapillary venules of inflamed ears is 3-fold less than controls from 1 hour to 24 hours after immunization

impaired leukocyte tethering or rolling ( J:114317 )

• less rolling leukocytes are observed in the postcapillary venules of inflamed ears six hours after immunization compared to controls

• velocity of these rolling leukocytes is greater than controls 24 hours after immunization

impaired neutrophil recruitment ( J:114317 )

• about 4-fold less Gr⁺ cells are found in inflamed ears compared to controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:114317 )

• about 2-3 fold less CD4⁺ T cells are recruited to inflamed ears compared to controls

decreased susceptibility to type IV hypersensitivity reaction ( J:114317 )

• OVA-sensitized mice have less swelling 12 to 24 hours after OVA injection in the ear compared to controls

cellular

abnormal leukocyte adhesion ( J:114317 )

• the number of adherent leukocytes observed in the postcapillary venules of inflamed ears is 3-fold less than controls from 1 hour to 24 hours after immunization

impaired leukocyte tethering or rolling ( J:114317 )

• less rolling leukocytes are observed in the postcapillary venules of inflamed ears six hours after immunization compared to controls

• velocity of these rolling leukocytes is greater than controls 24 hours after immunization

hematopoietic system

abnormal leukocyte adhesion ( J:114317 )

• the number of adherent leukocytes observed in the postcapillary venules of inflamed ears is 3-fold less than controls from 1 hour to 24 hours after immunization

impaired leukocyte tethering or rolling ( J:114317 )

• less rolling leukocytes are observed in the postcapillary venules of inflamed ears six hours after immunization compared to controls

• velocity of these rolling leukocytes is greater than controls 24 hours after immunization

impaired neutrophil recruitment ( J:114317 )

• about 4-fold less Gr⁺ cells are found in inflamed ears compared to controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:114317 )

• about 2-3 fold less CD4⁺ T cells are recruited to inflamed ears compared to controls