All Phenotypes Tg(Pdx1-cre/Esr1*)1Mga MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Pdx1-cre/Esr1*)1Mga
transgene insertion 1, Maureen A Gannon
MGI:3839433

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Neurog3^{tm1(Neurog3,cre/ERT)Ggu}/Neurog3^{tm1(Neurog3,cre/ERT)Ggu} Tg(Pdx1-cre/Esr1*)1Mga/0	involves: 129S6/SvEvTac	MGI:3850076
cn2	Neurog3^{tm1(Neurog3,cre/ERT)Ggu}/Neurog3^{tm1.1(cre/ERT)Ggu} Tg(Pdx1-cre/Esr1*)1Mga/0	involves: 129S6/SvEvTac	MGI:3850077

Allelic Composition	Neurog3^{tm1(Neurog3,cre/ERT)Ggu}/Neurog3^{tm1(Neurog3,cre/ERT)Ggu} Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3^{tm1(Neurog3,cre/ERT)Ggu} mutation (0 available); any Neurog3 mutation (18 available)
Tg(Pdx1-cre/Esr1*)1Mga mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell physiology ( J:150074 )

• after tamoxifen treatment, beta cell function is disrupted compared to in wild-type mice

• however, beta cells exhibit normal cell division and cell death

homeostasis/metabolism

impaired glucose tolerance ( J:150074 )

• in female mice 10 weeks after tamoxifen treatment

Allelic Composition	Neurog3^{tm1(Neurog3,cre/ERT)Ggu}/Neurog3^{tm1.1(cre/ERT)Ggu} Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3^{tm1.1(cre/ERT)Ggu} mutation (0 available); any Neurog3 mutation (18 available)
Neurog3^{tm1(Neurog3,cre/ERT)Ggu} mutation (0 available); any Neurog3 mutation (18 available)
Tg(Pdx1-cre/Esr1*)1Mga mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:150074 )

• in male mice 4 weeks after tamoxifen treatment

hyperglycemia ( J:150074 )

• in male mice 12 weeks after tamoxifen treatment

abnormal circulating insulin level ( J:150074 )

• 12 weeks after tamoxifen treatment, postglucose-challenge-serum-insulin levels are decreased unlike in similarly treated wild-type mice

impaired glucose tolerance ( J:150074 )

• in female mice 2 and 3 months after tamoxifen treatment and in male mice 12 weeks after tamoxifen treatment

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