Phenotypes associated with this allele

• Allele Symbol: Mterf3^tm1.1Lrsn
• Allele Name: targeted mutation 1.1, Nils-Goran Larsson
• Allele ID: MGI:3839255
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mterf3^tm1.1Lrsn/Mterf3^tm1.1Lrsn Tg(Ckmm-cre)5Khn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL	MGI:3839275

Genotype
MGI:3839275

cn1

• Allelic Composition: Mterf3^tm1.1Lrsn/Mterf3^tm1.1Lrsn; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:145125 )

• mice die by 18 weeks of age

cardiovascular system

abnormal myocardial fiber mitochondrial morphology ( J:145125 )

• mice exhibit an increase in relative mitochondrial mass in hearts unlike in wild-type mice

enlarged heart ( J:145125 )

• mice exhibit a gradual increase in heart size with abnormal mitochondria unlike in wild-type mice

cardiomyopathy ( J:145125 )

• mitochondrial

cellular

abnormal myocardial fiber mitochondrial morphology ( J:145125 )

• mice exhibit an increase in relative mitochondrial mass in hearts unlike in wild-type mice

abnormal mitochondrial physiology ( J:145125 )

• steady-state mitochondrial transcription is decreased compared to in wild-type cells

abnormal mitochondrial ATP synthesis coupled electron transport ( J:145125 )

• the enzymatic activity of all mitochondrial complexes in heart tissues is decreased compared to in wild-type mice

growth/size/body

enlarged heart ( J:145125 )

• mice exhibit a gradual increase in heart size with abnormal mitochondria unlike in wild-type mice

decreased body weight ( J:145125 )

• at 16 weeks of age

muscle

abnormal myocardial fiber mitochondrial morphology ( J:145125 )

• mice exhibit an increase in relative mitochondrial mass in hearts unlike in wild-type mice

cardiomyopathy ( J:145125 )

• mitochondrial