All Phenotypes Ptprh<tm1.1Mato> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptprh^tm1.1Mato
targeted mutation 1.1, Takashi Matozaki
MGI:3839028

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprh^tm1.1Mato/Ptprh^tm1.1Mato	involves: 129S4/SvJae * C57BL/6	MGI:3839103
cx2	Apc^Min/Apc⁺ Ptprh^tm1.1Mato/Ptprh^tm1.1Mato	involves: 129S4/SvJae * C57BL/6 * C57BL/6J	MGI:3839104

Allelic Composition	Ptprh^tm1.1Mato/Ptprh^tm1.1Mato
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprh^tm1.1Mato mutation (1 available); any Ptprh mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:146871 )

N	• mice exhibit normal intestinal epithelial cells and digestive function

Allelic Composition	Apc^Min/Apc⁺ Ptprh^tm1.1Mato/Ptprh^tm1.1Mato
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Ptprh^tm1.1Mato mutation (1 available); any Ptprh mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of induced tumors ( J:146871 )

• mice develop fewer small intestinal macroadenomas compared to Apc^Min heterozygotes

• however, proliferation and apoptosis within the tumor mass is the same as in Apc^Min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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