Phenotypes associated with this allele

• Allele Symbol: Igh-7^tm1.1Lam
• Allele Name: targeted mutation 1.1, Marinus C Lamers
• Allele ID: MGI:3838715
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-7^tm1.1Lam/Igh-7^tm1.1Lam	involves: BALB/c	MGI:3838745

Genotype
MGI:3838745

hm1

• Allelic Composition: Igh-7^tm1.1Lam/Igh-7^tm1.1Lam
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased mature B cell number ( J:146733 )

• there is a 94-98% decrease in the number of IgE-producing B cells found in mice after three rounds of immunization

decreased IgE level ( J:146733 )

• circulating IgE levels are reduced 94-98% in mice 7, 14, or 24 weeks of age

• antigen specific IgE antibodies are barely detectable after immunization

• the IgE response to N. brasiliensis infection is 13% of that in wild-type mice

hematopoietic system

decreased mature B cell number ( J:146733 )

• there is a 94-98% decrease in the number of IgE-producing B cells found in mice after three rounds of immunization

decreased IgE level ( J:146733 )

• circulating IgE levels are reduced 94-98% in mice 7, 14, or 24 weeks of age

• antigen specific IgE antibodies are barely detectable after immunization

• the IgE response to N. brasiliensis infection is 13% of that in wild-type mice