Phenotypes associated with this allele

• Allele Symbol: Igh-7^tm1Lam
• Allele Name: targeted mutation 1, Marinus C Lamers
• Allele ID: MGI:3838714
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-7^tm1Lam/Igh-7^tm1Lam	involves: BALB/c	MGI:3838744

Genotype
MGI:3838744

hm1

• Allelic Composition: Igh-7^tm1Lam/Igh-7^tm1Lam
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased mature B cell number ( J:146733 )

• there is a 50% decrease in the number of IgE-producing B cells found in mice after three rounds of immunization as compared to controls

decreased IgE level ( J:146733 )

• circulating IgE levels are reduced 50% in mice 7, 14, or 24 weeks of age

• antigen specific IgE antibodies are reduced 50-80% after immunization with a poor secondary response after a booster

• the IgE response to N. brasiliensis infection is 55% of that in wild-type mice

hematopoietic system

decreased mature B cell number ( J:146733 )

• there is a 50% decrease in the number of IgE-producing B cells found in mice after three rounds of immunization as compared to controls

decreased IgE level ( J:146733 )

• circulating IgE levels are reduced 50% in mice 7, 14, or 24 weeks of age

• antigen specific IgE antibodies are reduced 50-80% after immunization with a poor secondary response after a booster

• the IgE response to N. brasiliensis infection is 55% of that in wild-type mice