Phenotypes associated with this allele

• Allele Symbol: Id2^tm1Mais
• Allele Name: targeted mutation 1, Mark A Israel
• Allele ID: MGI:3838359
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Id2^tm1Mais/Id2^tm1Mais	involves: 129X1/SvJ * C57BL/6	MGI:3838362
hm2	Id2^tm1Mais/Id2^tm1Mais	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:3838364

Genotype
MGI:3838362

hm1

• Allelic Composition: Id2^tm1Mais/Id2^tm1Mais
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:146624 )

• Background Sensitivity: expected number of homozygotes are born but less than 1% of mice survive post-natal and early post-weaning phase compared to a 10% survivor rate for outbred homozygotes

growth/size/body

decreased lean body mass ( J:146624 )

• mice are lean and have a low level of fat storage

immune system

abnormal immune system physiology ( J:146624 )

• mice have a higher survivor rate when housed under germ free conditions and are given sterile food and antibiotics in the water

endocrine/exocrine glands

abnormal lactation ( J:146624 )

♀ • homozygote mothers are unable to nurture pups suggesting a lactation defect

integument

abnormal lactation ( J:146624 )

♀ • homozygote mothers are unable to nurture pups suggesting a lactation defect

Genotype
MGI:3838364

hm2

• Allelic Composition: Id2^tm1Mais/Id2^tm1Mais
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

mortality/aging

decreased survivor rate ( J:146624 )

• Background Sensitivity: expected number of homozygotes are born but only 10% of mice survive post-natal and early post-weaning phase

• Background Sensitivity: a 10% survival rate is significantly higher than the <1% survivor rate for mice on a 129X1/SvJ * C57BL/6 background

growth/size/body

weight loss ( J:146624 )

• mice weigh 27% less than controls

behavior/neurological

decreased locomotor activity ( J:146624 )

• mice have a 70% reduction in wheel activity as measured by wheel rotation per 24 hour period

• this reduced activity was limited to the running wheel since activity measured by a passive infrared beam was similar to controls

arrhythmic circadian behavior persistence ( J:146624 )

• 25% of mice completely lose circadian rhythms under constant dark conditions as evidenced by random wheel activity throughout a 24 hour period

• several mice over 6 months of age develop antiphase diurnal rhythms while maintaining appropriate phase-response curves

abnormal circadian behavior phase ( J:146624 )

• mice entrained to a 12:12 light-dark cycle became active around the transition to lights-off

• mutant mice re-entrain to a 10 hour delay in the dark cycle within 2.46 days compared to 4.75 for controls

• phase shift of mutant mice is significantly greater when transferred to an all light cycle (3.54 hours versus 5.87 hours)