Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation
(0 available);
any
Gna11 mutation
(21 available)
Gnaqtm2Soff mutation
(0 available);
any
Gnaq mutation
(24 available)
Tg(Tek-icre/ERT2)1Soff mutation
(1 available)
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cardiovascular system
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• in response to tamoxifen
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• almost complete lost of dilation in response to flow
• inhibited acethylcholine-induced vasodilation
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal
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• in response to ligation of the external carotid artery, mice exhibit a strong reduction in neointima formation compared with control mice
• however, there is no change in the diameter of the common carotid artery
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homeostasis/metabolism
muscle
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• almost complete lost of dilation in response to flow
• inhibited acethylcholine-induced vasodilation
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2ry2tm1c(EUCOMM)Hmgu mutation
(0 available);
any
P2ry2 mutation
(18 available)
Tg(Tek-icre/ERT2)1Soff mutation
(1 available)
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cardiovascular system
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• almost complete lost of dilation in response to flow
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal
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muscle
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• almost complete lost of dilation in response to flow
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm2.1Soff mutation
(0 available);
any
Gna13 mutation
(12 available)
Tg(Tek-icre/ERT2)1Soff mutation
(1 available)
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cardiovascular system
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N |
• tamoxifen-treated mice respond similar to wild-type controls in experiments testing response to anaphylactic shock
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation
(0 available);
any
Gna11 mutation
(21 available)
Gnaqtm2Soff mutation
(0 available);
any
Gnaq mutation
(24 available)
Tg(Tek-icre/ERT2)1Soff mutation
(1 available)
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cardiovascular system
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• in mice with induction of cre recombinase, basal permeability is lower than controls
• vascular permeability does not increase above basal levels in response to histamine, IgE, platelet-activating factor (PAF), lysophosphatidic acid (LPA), or F2r-activating peptide
• mice are resistant to death resulting from PAF-induced shock
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immune system
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N |
• while resistant to shock induced by IgE or vasoactive substances, mice are not resistant to shock induced by LPS
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• tamoxifen treated mice are resistant to IgE-induced anaphylactic shock
• in an anti-DNP model, mice only have transient drops in systolic blood pressure compared to the sustained (>90 min) drops that occur in controls
• in an anti-BSA model, all mice survive anaphylactic challenge with only moderate decreases in body temperature compared to controls that suffer from severe hypothermia and death within 20 min of challenge
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapre3tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Mapre3 mutation
(17 available)
Tg(Tek-icre/ERT2)1Soff mutation
(1 available)
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cardiovascular system
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• after infusion with a peptide agonist of PAR-1 (F2r), lung vasculature fails to exhibit hyper-permeability unlike in wild-type mice
• however, untreated mice exhibit normal adult microvasculature in the lungs
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Analysis Tools