All Phenotypes Adrb2<tm1Kry> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adrb2^tm1Kry
targeted mutation 1, Gerard Karsenty
MGI:3837346

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Adipoq^tm1Ish/Adipoq^tm1Ish Adrb2^tm1Kry/Adrb2^tm1Kry Tg(Col1a1-cre)1Kry/0	involves: 129S7/SvEvBrd * C57BL/6J * FVB	MGI:5520076
cn2	Adrb2^tm1Kry/Adrb2⁺ Lep^ob/Lep⁺ Tg(Col1a1-cre)1Kry/0	involves: C57BL/6 * C57BL/10J * FVB	MGI:3837367
cn3	Adrb2^tm1Kry/Adrb2^tm1Kry Tg(Col1a1-cre)1Kry/0	involves: FVB	MGI:3837366

Allelic Composition	Adipoq^tm1Ish/Adipoq^tm1Ish Adrb2^tm1Kry/Adrb2^tm1Kry Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Ish mutation (0 available); any Adipoq mutation (40 available)
Adrb2^tm1Kry mutation (0 available); any Adrb2 mutation (32 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mass ( J:199264 )

• compared with wild-type mice and Adipoq^tm1Ish homozygotes

Allelic Composition	Adrb2^tm1Kry/Adrb2⁺ Lep^ob/Lep⁺ Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: C57BL/6 * C57BL/10J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adrb2^tm1Kry mutation (0 available); any Adrb2 mutation (32 available)
Lep^ob mutation (5 available); any Lep mutation (19 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:145998 )

• mice exhibit postprandial low blood glucose levels compared to in wild-type mice

increased circulating insulin level ( J:145998 )

Allelic Composition	Adrb2^tm1Kry/Adrb2^tm1Kry Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adrb2^tm1Kry mutation (0 available); any Adrb2 mutation (32 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal insulin secretion ( J:145998 )

• mice treated intracerebroventricularly with leptin fail to exhibit a decrease in glucose-stimulated insulin secretion as in wild-type mice

decreased circulating glucose level ( J:145998 )

• mice exhibit postprandial low blood glucose levels compared to in wild-type mice

increased circulating insulin level ( J:145998 )

• mice exhibit elevated serum insulin levels compared to in wild-type mice that could not be increased by treatment with propranolol as in wild-type mice

• mice treated intracerebroventricularly with leptin fail to exhibit a decrease in glucose-stimulated circulating insulin levels as in wild-type mice

• however, insulin tolerance is normal

endocrine/exocrine glands

abnormal insulin secretion ( J:145998 )

• mice treated intracerebroventricularly with leptin fail to exhibit a decrease in glucose-stimulated insulin secretion as in wild-type mice

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