All Phenotypes Thrb<tm1Mkni> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Thrb^tm1Mkni
targeted mutation 1, Marlies Knipper
MGI:3836780

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Thrb^tm1Df/Thrb^tm1Mkni Tg(Pres-cre)1Jnz/0	involves: 129S1/Sv * C57BL/6J * FVB/NJ	MGI:3836781
cn2	Thrb^tm1Mkni/Thrb^tm1Mkni Hprt1^{tm1(TG-cre)1Sasr}/Y	involves: 129/Sv * C57BL/6	MGI:5576933
cn3	Thrb^tm1Mkni/Thrb⁺ Hprt1^{tm1(TG-cre)1Sasr}/Y	involves: 129/Sv * C57BL/6	MGI:5576934

Allelic Composition	Thrb^tm1Df/Thrb^tm1Mkni Tg(Pres-cre)1Jnz/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pres-cre)1Jnz mutation (0 available)
Thrb^tm1Df mutation (1 available); any Thrb mutation (41 available)
Thrb^tm1Mkni mutation (0 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlear inner hair cell physiology ( J:145941 )

• voltage activated K+ currents are absent from inner hair cells

increased or absent threshold for auditory brainstem response ( J:145941 )

• significant increase in ABR thresholds at frequencies less than 8 kHz

nervous system

abnormal cochlear inner hair cell physiology ( J:145941 )

• voltage activated K+ currents are absent from inner hair cells

Allelic Composition	Thrb^tm1Mkni/Thrb^tm1Mkni Hprt1^{tm1(TG-cre)1Sasr}/Y
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(TG-cre)1Sasr} mutation (0 available); any Hprt1 mutation (1279 available)
Thrb^tm1Mkni mutation (0 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased thyroid gland weight ( J:208718 )

• significantly reduced at 2 months, compared to controls

growth/size/body

growth/size/body region phenotype ( J:208718 )

N	• body weight is not different from wild-type in 2-month old males

homeostasis/metabolism

decreased circulating thyroid-stimulating hormone level ( J:208718 )

• serum levels are decreased by 20%

abnormal thyroid hormone level ( J:208718 )

• thyroid free T3 levels are not different from controls, but free rT3 levels are significantly elevated in the thyroid increased in 20 month old males; T4/rT3 ratios are elevated

increased thyroxine level ( J:208718 )

• thyroid free T4 and thyroglobulin-bound T4 levels in the thyroid gland are significantly increased in 20 month old males; T4/T3 ratios are elevated

increased circulating levels of thyroid hormone ( J:208718 )

• T3 levels are unchanged, but rT3 (reverse triiodothyronine) levels are significantly increased

increased circulating thyroxine level ( J:208718 )

• serum levels are significantly increased at 2 months

Allelic Composition	Thrb^tm1Mkni/Thrb⁺ Hprt1^{tm1(TG-cre)1Sasr}/Y
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased thyroid gland weight ( J:208718 )

• significantly reduced at 2 months, compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24