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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Drd1-cre)EY262Gsat
transgene insertion EY262, GENSAT Project at Rockefeller University
MGI:3836631
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ehmt2tm1.1Tara/Ehmt2tm1.1Tara
Tg(Drd1-cre)EY262Gsat/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4418568
cn2
 		Nlgn3tm4.1Sud/Y
Tg(Drd1-cre)EY262Gsat/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:5660864
cn3
 		Nlgn3tm1Sud/Y
Tg(Drd1-cre)EY262Gsat/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5660866
cn4
 		Mir128-2tm1.1Ans/Mir128-2tm1.1Ans
Tg(Drd1-cre)EY262Gsat/0 		involves: BALB/cJ * C57BL/6J * FVB/N MGI:5563804
cn5
 		Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd1-cre)EY262Gsat/0
Tg(Drd1-EGFP)X60Gsat/0 		involves: C57BL/6 * FVB/N * FVB/NTac MGI:4830459


Genotype
MGI:4418568
cn1
Allelic
Composition		 Ehmt2tm1.1Tara/Ehmt2tm1.1Tara
Tg(Drd1-cre)EY262Gsat/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Tara mutation (0 available); any Ehmt2 mutation (55 available)
Tg(Drd1-cre)EY262Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired behavioral response to xenobiotic ( J:155739 )
• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses
decreased locomotor activity ( J:155739 )
• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses

nervous system
nervous system phenotype ( J:155739 )
N
• no major impact on regulation of neuronal morphology and basal electrophysiological features of Drd2-expressing MSNs in the striatum




Genotype
MGI:5660864
cn2
Allelic
Composition		 Nlgn3tm4.1Sud/Y
Tg(Drd1-cre)EY262Gsat/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm4.1Sud mutation (0 available); any Nlgn3 mutation (35 available)
Tg(Drd1-cre)EY262Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
enhanced learning ( J:214636 )
• mice exhibit increased learning rate on the accelerating rotarod
hyperactivity ( J:214636 )
• mice exhibit increased open-field activity




Genotype
MGI:5660866
cn3
Allelic
Composition		 Nlgn3tm1Sud/Y
Tg(Drd1-cre)EY262Gsat/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Sud mutation (1 available); any Nlgn3 mutation (35 available)
Tg(Drd1-cre)EY262Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
enhanced learning ( J:214636 )
• mice exhibit increased learning rate but similar initial coordination on the accelerating rotarod
increased stereotypic behavior ( J:214636 )
• mice perform similarly to wild-type littermates on the first trial of an accelerating rotarod, however in the last several trials, mice exhibit enhanced performance, with increased time on the rotarod before falling off compared to wild-type mice, indicating enhanced formation of repetitive motor routine




Genotype
MGI:5563804
cn4
Allelic
Composition		 Mir128-2tm1.1Ans/Mir128-2tm1.1Ans
Tg(Drd1-cre)EY262Gsat/0
Genetic
Background		 involves: BALB/cJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2tm1.1Ans mutation (0 available); any Mir128-2 mutation (0 available)
Tg(Drd1-cre)EY262Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:205260 )
• at about 5 months of age

behavior/neurological
hyperactivity ( J:205260 )
• juvenile
• administration of a MAP2K1 specific inhibitor SL327 normalizes locomotor activity

nervous system
increased dendritic spine number ( J:205260 )
• about a 20% increase in functional dendritic spines in striatal slices
abnormal action potential ( J:205260 )
• enhanced dendritic excitability in striatal slices




Genotype
MGI:4830459
cn5
Allelic
Composition		 Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd1-cre)EY262Gsat/0
Tg(Drd1-EGFP)X60Gsat/0
Genetic
Background		 involves: C57BL/6 * FVB/N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r1btm5.1Pggd mutation (0 available); any Ppp1r1b mutation (18 available)
Tg(Drd1-cre)EY262Gsat mutation (2 available)
Tg(Drd1-EGFP)X60Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
reduced long-term potentiation ( J:163700 )
• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses

behavior/neurological
impaired behavioral response to xenobiotic ( J:163700 )
• haloperidol-induced catalepsy is reduced
• L-DOPA-induced dyskinesia. is absent
decreased locomotor activity ( J:163700 )
• in an open-field test




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory