Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Tara mutation
(0 available);
any
Ehmt2 mutation
(46 available)
Tg(Drd1-cre)EY262Gsat mutation
(2 available)
|
|
|
behavior/neurological
|
|
• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses
|
|
|
• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses
|
nervous system
|
N |
• no major impact on regulation of neuronal morphology and basal electrophysiological features of Drd2-expressing MSNs in the striatum
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(21 available)
Tg(Drd1-cre)EY262Gsat mutation
(2 available)
|
|
|
behavior/neurological
 |
• mice exhibit increased learning rate on the accelerating rotarod
|
|
|
• mice exhibit increased open-field activity
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Sud mutation
(1 available);
any
Nlgn3 mutation
(21 available)
Tg(Drd1-cre)EY262Gsat mutation
(2 available)
|
|
|
behavior/neurological
|
|
• mice exhibit increased learning rate but similar initial coordination on the accelerating rotarod
|
|
|
• mice perform similarly to wild-type littermates on the first trial of an accelerating rotarod, however in the last several trials, mice exhibit enhanced performance, with increased time on the rotarod before falling off compared to wild-type mice, indicating enhanced formation of repetitive motor routine
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2tm1.1Ans mutation
(0 available);
any
Mir128-2 mutation
(0 available)
Tg(Drd1-cre)EY262Gsat mutation
(2 available)
|
|
|
mortality/aging
|
|
• at about 5 months of age
|
behavior/neurological
|
|
• juvenile
• administration of a MAP2K1 specific inhibitor SL327 normalizes locomotor activity
|
nervous system
|
|
• about a 20% increase in functional dendritic spines in striatal slices
|
|
|
• enhanced dendritic excitability in striatal slices
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r1btm5.1Pggd mutation
(0 available);
any
Ppp1r1b mutation
(12 available)
Tg(Drd1-cre)EY262Gsat mutation
(2 available)
Tg(Drd1-EGFP)X60Gsat mutation
(1 available)
|
|
|
nervous system
|
|
• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses
|
behavior/neurological
|
|
• haloperidol-induced catalepsy is reduced
• L-DOPA-induced dyskinesia. is absent
|
Analysis Tools