Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm3Mnz mutation
(1 available);
any
Igh mutation
(43 available)
Ightm4.1Mnz mutation
(0 available);
any
Igh mutation
(43 available)
|
|
|
immune system
N |
• mice exhibit normal B cell development and class switch recombination to IgG1 following stimulation with LPS and IL4
|
hematopoietic system
|
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells
|
immune system
|
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells
|
cellular
|
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles
|
immune system
|
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles
|
hematopoietic system
|
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles
|
cellular
|
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles
|
immune system
|
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles
|
hematopoietic system
|
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles
|
cellular
|
• activated B cells transfected with yeast-derived I-SceI endonuclease have a high incidence of chromosomal translocations involving chromosomes 12 and 15
• chromosome fusions occur within 2.2 kb of the I-SceI recognition sites that are present in the Myc and Igh mutant alleles
• out of 21 translocation junctions, 19 involved 1-7 bps of microhomology (average microhomology of 2.9 bps) and two included insertions
• translocation rates are similar when B cells are transfected with Aicda, cre, or SceI genes
|