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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli
transgene insertion 14, Jack A Elias
MGI:3836020
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Casp3tm1Flv/Casp3tm1Flv
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0 		involves: 129S1/Sv * C57BL/6 * CBA MGI:5008743
cx2
 		Ctsstm1Hap/Ctsstm1Hap
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:5008742
tg3
 		Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0 involves: C57BL/6 * CBA MGI:5008744


Genotype
MGI:5008743
cx1
Allelic
Composition		 Casp3tm1Flv/Casp3tm1Flv
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp3tm1Flv mutation (1 available); any Casp3 mutation (31 available)
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
emphysema ( J:100854 )
• following treatment with doxycycline but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
abnormal lung volume ( J:100854 )
• doxycycline-treated mice exhibit increased lung volume compared to in wild-type mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
increased lung compliance ( J:100854 )
• following treatment with doxycycline but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

immune system
increased neutrophil cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
increased lymphocyte cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
increased macrophage cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

cellular
increased apoptosis ( J:100854 )
• in lung cells following treatment with doxycycline but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

hematopoietic system
increased neutrophil cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
increased lymphocyte cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
increased macrophage cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice




Genotype
MGI:5008742
cx2
Allelic
Composition		 Ctsstm1Hap/Ctsstm1Hap
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsstm1Hap mutation (3 available); any Ctss mutation (30 available)
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
emphysema ( J:100854 )
• following treatment with doxycycline but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
abnormal lung volume ( J:100854 )
• doxycycline-treated mice exhibit increased lung volume compared to in wild-type mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
increased lung compliance ( J:100854 )
• following treatment with doxycycline but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

immune system
increased neutrophil cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
increased lymphocyte cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
increased macrophage cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

cellular
increased apoptosis ( J:100854 )
• in lung cells following treatment with doxycycline but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

hematopoietic system
increased neutrophil cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
increased lymphocyte cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice
increased macrophage cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice




Genotype
MGI:5008744
tg3
Allelic
Composition		 Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
emphysema ( J:100854 )
• following treatment with doxycycline
abnormal lung volume ( J:100854 )
• doxycycline-treated mice exhibit increased lung volume compared to in wild-type mice
increased lung compliance ( J:100854 )
• following treatment with doxycycline

immune system
increased neutrophil cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice
increased lymphocyte cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice
increased macrophage cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice

cellular
increased apoptosis ( J:100854 )
• in lung cells following treatment with doxycycline

hematopoietic system
increased neutrophil cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice
increased lymphocyte cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice
increased macrophage cell number ( J:100854 )
• in the bronchoalveolar lavage of doxycycline-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory