All Phenotypes Tg(Slc6a3-cre/ERT2)1Span MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst Rrn3^tm1.1Igt/Rrn3^tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0	involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J	MGI:6113544
cn2	Crhr1^tm2Wrst/Crhr1^tm2Wrst Tg(Slc6a3-cre/ERT2)1Span/0	involves: 129S2/SvPas * C57BL/6J	MGI:5294461
cn3	Lmx1a^tm1Tpe/Lmx1a^tm1Tpe Lmx1b^tm1Zfc/Lmx1b^tm1Zfc Tg(Slc6a3-cre/ERT2)1Span/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:5647909
cn4	Rrn3^tm1.1Igt/Rrn3^tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0	involves: 129/Sv * C57BL/6	MGI:6113542

Allelic Composition	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst Rrn3^tm1.1Igt/Rrn3^tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7^Gt(XE726)Byg mutation (1 available); any Park7 mutation (53 available)
Pink1^tm1.1Wrst mutation (0 available); any Pink1 mutation (42 available)
Rrn3^tm1.1Igt mutation (1 available); any Rrn3 mutation (41 available)
Tg(Slc6a3-cre/ERT2)1Span mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal nucleolus morphology ( J:242309 )

• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants

abnormal cell physiology ( J:242309 )

• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants

Allelic Composition	Crhr1^tm2Wrst/Crhr1^tm2Wrst Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1^tm2Wrst mutation (0 available); any Crhr1 mutation (26 available)
Tg(Slc6a3-cre/ERT2)1Span mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:176339 )

N	• tamoxifen-treated mice exhibit normal anxiety-related behavior, behavior in a forced swim test, and auditory fear conditioning

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:176339 )

N	• tamoxifen-treated mice exhibit normal basal and stress-induced corticosterone levels

Allelic Composition	Lmx1a^tm1Tpe/Lmx1a^tm1Tpe Lmx1b^tm1Zfc/Lmx1b^tm1Zfc Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1a^tm1Tpe mutation (0 available); any Lmx1a mutation (20 available)
Lmx1b^tm1Zfc mutation (0 available); any Lmx1b mutation (16 available)
Tg(Slc6a3-cre/ERT2)1Span mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal synaptic bouton morphology ( J:222854 )

• abnormally enlarged nerve terminals are seen in mice 4 weeks after treatment with tamoxifen at 4 weeks of age, showing fewer synaptic vesicles at active zones and an increase in the number of autophagic-lysosomal vesicles

neurodegeneration ( J:222854 )

• striatal expression of dopamine transporter (DAT) is reduced in the ventral striatum 18 months after tamoxifen treatment indicating dopaminergic neuron loss, however, no loss of TH or DAT expression in the dorsal striatum and no loss of TH+ cells are seen at this time point

homeostasis/metabolism

decreased dopamine level ( J:222854 )

• dopamine and its metabolites are diminished after tamoxifen treatment of 4 week old mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:168232 )

• motor dysfunction in mice injected with tamoxifen at 2 months of age

cellular

abnormal nucleolus morphology ( J:242309 )

• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice

abnormal mitochondrial morphology ( J:168232 )

• about 40% decrease in COX activity is seen 2 weeks after tamoxifen treatment, indicating mitochondrial damage is an early consequence of nucleolar damage

abnormal cell physiology ( J:242309 )

• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice

increased cellular sensitivity to oxidative stress ( J:168232 )

• dopaminergic neurons of tamoxifen-induced mice are more vulnerable to the oxidative damage induced by MPTP than controls showing an approximate 40% loss of neurons compared to 15% in controls

oxidative stress ( J:168232 )

• dopaminergic neurons show higher levels of oxidative stress markers at 4 weeks after tamoxifen treatment

homeostasis/metabolism

decreased dopamine level ( J:168232 )

• mice injected with tamoxifen at 2 months of age exhibit a decline in dopamine content in the striatum

nervous system

loss of dopaminergic neurons ( J:168232 )

• mice injected with tamoxifen at 2 months of age show a progressive differential loss of dopaminergic neurons in substantia nigra and ventral tegmental area

• tamoxifen-induced mice treated with pifithrin-alpha, a chemical inhibitor of Trp53 show prevention of dopaminergic neuron loss

neurodegeneration ( J:168232 )

• mice injected with tamoxifen at 2 months of age exhibit neurodegeneration of TH+ neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:168232 , J:242309

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23