All Phenotypes Erbb3<tm3Cbm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Erbb3^tm3Cbm
targeted mutation 3, Carmen Birchmeier
MGI:3835516

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Erbb3^tm2Cbm/Erbb3^tm3Cbm Erbb4^tm1Fej/Erbb4^tm1Fej Cnp^tm1(cre)Kan/?	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3835562
cn2	Erbb3^tm3Cbm/Erbb3^tm3Cbm Gt(ROSA)26Sor^{tm8(Map2k1*,-EGFP)Rsky}/? Tg(Dhh-cre)1Mejr/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5588163
cn3	Erbb3^tm3Cbm/Erbb3^tm3Cbm Gt(ROSA)26Sor^{tm7(Pik3ca*,-EGFP)Rsky}/? Tg(Dhh-cre)1Mejr/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5588164
cn4	Erbb3^tm3Cbm/Erbb3^tm3Cbm Tg(Dhh-cre)1Mejr/0	involves: 129P2/OlaHsd * FVB/N	MGI:5588162

Allelic Composition	Erbb3^tm2Cbm/Erbb3^tm3Cbm Erbb4^tm1Fej/Erbb4^tm1Fej Cnp^tm1(cre)Kan/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnp^tm1(cre)Kan mutation (0 available); any Cnp mutation (29 available)
Erbb3^tm2Cbm mutation (0 available); any Erbb3 mutation (44 available)
Erbb3^tm3Cbm mutation (0 available); any Erbb3 mutation (44 available)
Erbb4^tm1Fej mutation (1 available); any Erbb4 mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:145464 )

• develop to term but die in the second post natal week

nervous system

nervous system phenotype ( J:145464 )

N	• central nervous system myelination is normal up to 11 days of age (optic nerve and corpus callosum)

abnormal myelination ( J:145464 )

• severely defective myelination in the peripheral nervous system

Allelic Composition	Erbb3^tm3Cbm/Erbb3^tm3Cbm Gt(ROSA)26Sor^{tm8(Map2k1*,-EGFP)Rsky}/? Tg(Dhh-cre)1Mejr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3^tm3Cbm mutation (0 available); any Erbb3 mutation (44 available)
Gt(ROSA)26Sor^{tm8(Map2k1*,-EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Dhh-cre)1Mejr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased myelin sheath thickness ( J:207470 )

• at P15, the myelin of peripheral axons is thinner but axons are hypermyelinated at P90

abnormal myelination ( J:207470 )

• at P15 and P90, 36.7% and 17.8% of axons with diameters >1 um are nonmyelinated, respectively compared to 3.5% and 0.8% in controls

hypermyelination ( J:207470 )

• axons are hypermyelinated at P90

• however, mice show rescue of Schwann cell development and Schwan cells are able to myelinate

Allelic Composition	Erbb3^tm3Cbm/Erbb3^tm3Cbm Gt(ROSA)26Sor^{tm7(Pik3ca*,-EGFP)Rsky}/? Tg(Dhh-cre)1Mejr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3^tm3Cbm mutation (0 available); any Erbb3 mutation (44 available)
Gt(ROSA)26Sor^{tm7(Pik3ca*,-EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Dhh-cre)1Mejr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelination ( J:207470 )

• myelination is not seen

Allelic Composition	Erbb3^tm3Cbm/Erbb3^tm3Cbm Tg(Dhh-cre)1Mejr/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3^tm3Cbm mutation (0 available); any Erbb3 mutation (44 available)
Tg(Dhh-cre)1Mejr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent Schwann cells ( J:207470 )

• almost complete absence of Schwann cells

cellular

absent Schwann cells ( J:207470 )

• almost complete absence of Schwann cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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