Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation
(0 available);
any
Cnp mutation
(26 available)
Erbb3tm2Cbm mutation
(0 available);
any
Erbb3 mutation
(47 available)
Erbb3tm3Cbm mutation
(0 available);
any
Erbb3 mutation
(47 available)
Erbb4tm1Fej mutation
(1 available);
any
Erbb4 mutation
(87 available)
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mortality/aging
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• develop to term but die in the second post natal week
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nervous system
N |
• central nervous system myelination is normal up to 11 days of age (optic nerve and corpus callosum)
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• severely defective myelination in the peripheral nervous system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3tm3Cbm mutation
(0 available);
any
Erbb3 mutation
(47 available)
Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Dhh-cre)1Mejr mutation
(1 available)
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nervous system
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• at P15, the myelin of peripheral axons is thinner but axons are hypermyelinated at P90
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• at P15 and P90, 36.7% and 17.8% of axons with diameters >1 um are nonmyelinated, respectively compared to 3.5% and 0.8% in controls
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• axons are hypermyelinated at P90
• however, mice show rescue of Schwann cell development and Schwan cells are able to myelinate
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3tm3Cbm mutation
(0 available);
any
Erbb3 mutation
(47 available)
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Dhh-cre)1Mejr mutation
(1 available)
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nervous system
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• myelination is not seen
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3tm3Cbm mutation
(0 available);
any
Erbb3 mutation
(47 available)
Tg(Dhh-cre)1Mejr mutation
(1 available)
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nervous system
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• almost complete absence of Schwann cells
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