Erbb3^tm3Cbm
Targeted Allele Detail

Summary

• Symbol: Erbb3^tm3Cbm
• Name: erb-b2 receptor tyrosine kinase 3; targeted mutation 3, Carmen Birchmeier
• MGI ID: MGI:3835516
• Synonyms: ErbB3^fl, ErbB3^flox
• Gene: Erbb3 Location: Chr10:128403392-128425504 bp, - strand Genetic Position: Chr10, 77.1 cM
• Alliance: Erbb3^tm3Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145464
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sequences were inserted into a unique Pac1 site located 5' of exons 10 and 11. The human ERBB3 cDNA was ligated in frame into exon 12 using a Bcll site. The targeting vector also contained a neomycin-resistance cassette flanked by loxP sites and exon 17 and downstream sequences. The neomycin-resistance cassette was removed by Cre-recombination in ES cells. (J:207470)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb3 Mutation: 47 strains or lines available

References

• Original: J:145464 Brinkmann BG, et al., Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron. 2008 Aug 28;59(4):581-95
• All: 6 reference(s)