Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(RNAi:Bmpr2)Dliu}
• Allele Name: targeted mutation 1, Dong Liu
• Allele ID: MGI:3835030
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^tm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor^tm1(RNAi:Bmpr2)Dliu	involves: 129 * C57BL/6J	MGI:3835046
ht2	Gt(ROSA)26Sor^tm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor^+	involves: 129 * C57BL/6J	MGI:3835045

Genotype
MGI:3835046

hm1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(RNAi:Bmpr2)Dliu}/Gt(ROSA)26Sor^{tm1(RNAi:Bmpr2)Dliu}
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:145514 )

• normal at birth

• 100% dead by day 150

cardiovascular system

gastrointestinal hemorrhage ( J:145514 )

• earlier onset

• hemorrhage extends into the upper intestinal tract and the stomach

digestive/alimentary system

gastrointestinal hemorrhage ( J:145514 )

• earlier onset

• hemorrhage extends into the upper intestinal tract and the stomach

Genotype
MGI:3835045

ht2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(RNAi:Bmpr2)Dliu}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

premature death ( J:145514 )

• normal at birth

• 100% dead by day 300

hematopoietic system

extramedullary hematopoiesis ( J:145514 )

anemia ( J:145514 )

decreased erythrocyte cell number ( J:145514 )

• greatly reduced red blood cell number

reticulocytosis ( J:145514 )

• massively increased number of reticulocytes in the circulation

abnormal spleen morphology ( J:145514 )

enlarged spleen ( J:145514 )

• splenomegaly

abnormal spleen white pulp morphology ( J:145514 )

• disrupted follicle structure

respiratory system

respiratory distress ( J:145514 )

• dyspnea, difficulty breathing

cardiovascular system

abnormal blood vessel morphology ( J:145514 )

• angiodysplasia-like lesions in the ileum and colon

• hemorrhage of capillaries and thin walled vascular channels

abnormal pulmonary artery morphology ( J:145514 )

• no pulmonary artery hypertrophy

• dilated preacinar pulmonary arteries

• disorganized adventitia

• thin tunica media

• reduced wall thickness

decreased angiogenesis ( J:145514 )

vascular smooth muscle hypoplasia ( J:145514 )

• regions of both intestinal and pulmonary arteries lack smooth muscle

intestinal hemorrhage ( J:145514 )

• massive intestinal hemorrhage, mostly in the cecum or at the ileocecal junction

growth/size/body

cachexia ( J:145514 )

enlarged spleen ( J:145514 )

• splenomegaly

skeleton

skeleton phenotype ( J:145514 )

N • bone marrow morphology is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:145514 )

N • blood clotting function is normal

digestive/alimentary system

intestinal hemorrhage ( J:145514 )

• massive intestinal hemorrhage, mostly in the cecum or at the ileocecal junction

intestine polyps ( J:145514 )

• large solitary polyps develop in the small and large intestine

• some with irregular tubular cysts and distorted glands

muscle

vascular smooth muscle hypoplasia ( J:145514 )

• regions of both intestinal and pulmonary arteries lack smooth muscle

immune system

abnormal spleen morphology ( J:145514 )

enlarged spleen ( J:145514 )

• splenomegaly

abnormal spleen white pulp morphology ( J:145514 )

• disrupted follicle structure

integument

pallor ( J:145514 )