mortality/aging
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• 50% of doxycycline-treated mice die due to generally compromised physiological state secondary to renal failure despite frequent bladder irrigations
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neoplasm
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• at 24 weeks after doxycycline induction, mice develop prostate adenocarcinomas that exhibit epithelial-mesenchyme transition
• doxycycline-induced prostate adenomas can compress the bladder, originate from epithelial cells and express luminal, intermediate and basal cell markers
• doxycycline-treated mice that are subsequently castrated exhibit reduced prostate tumor proliferation compared to pre-castration
• withdrawal of doxycycline does not affect tumor cell proliferation
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endocrine/exocrine glands
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• at 16 weeks after doxycycline induction, prostates exhibit basaloid hyperplasia driven by urogenital epithelium unlike in wild-type mice
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• at 24 weeks after doxycycline induction, mice develop prostate adenocarcinomas that exhibit epithelial-mesenchyme transition
• doxycycline-induced prostate adenomas can compress the bladder, originate from epithelial cells and express luminal, intermediate and basal cell markers
• doxycycline-treated mice that are subsequently castrated exhibit reduced prostate tumor proliferation compared to pre-castration
• withdrawal of doxycycline does not affect tumor cell proliferation
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• at 5 weeks after doxycycline induction, prostates exhibit a moderate degree of aberrant proliferation unlike in wild-type mice
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reproductive system
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• at 16 weeks after doxycycline induction, prostates exhibit basaloid hyperplasia driven by urogenital epithelium unlike in wild-type mice
|
|
• at 24 weeks after doxycycline induction, mice develop prostate adenocarcinomas that exhibit epithelial-mesenchyme transition
• doxycycline-induced prostate adenomas can compress the bladder, originate from epithelial cells and express luminal, intermediate and basal cell markers
• doxycycline-treated mice that are subsequently castrated exhibit reduced prostate tumor proliferation compared to pre-castration
• withdrawal of doxycycline does not affect tumor cell proliferation
|
|
• at 5 weeks after doxycycline induction, prostates exhibit a moderate degree of aberrant proliferation unlike in wild-type mice
|