All Phenotypes Pak1<tm1Cher> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pak1^tm1Cher/Pak1^tm1Cher	B6.129S2-Pak1^tm1Cher	MGI:3834754
hm2	Pak1^tm1Cher/Pak1^tm1Cher	involves: 129S2/SvPas	MGI:5494663
cx3	Nf1^tm1Tyj/Nf1⁺ Pak1^tm1Cher/Pak1^tm1Cher	involves: 129S2/SvPas * C57BL/6	MGI:3834706

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mast cell physiology ( J:142439 )

• bone marrow derived mast cells proliferate at 60% the rate as controls when cultured for three days with SCF

• these mast cells also have a third slower migration rate towards SCF in transwell assays than controls

• in vivo, less mast cells migrate to the skin when SCF is administered than in controls

decreased mast cell degranulation ( J:145444 )

• bone marrow derived mast cells have a 3-fold reduction in granule release upon Fc-epsilionRI stimulation compared to controls

• calcium flux from the extracellular environment is significantly reduced after receptor stimulation compared to controls

• when passive cutaneous anaphylaxis (PCA) is induced in the ear of mice, the mast cells fail to respond

• similar results are observed when mutant mast cells are transferred into mast-cell deficient mice and PCA is induced

hematopoietic system

abnormal mast cell physiology ( J:142439 )

• bone marrow derived mast cells proliferate at 60% the rate as controls when cultured for three days with SCF

• these mast cells also have a third slower migration rate towards SCF in transwell assays than controls

• in vivo, less mast cells migrate to the skin when SCF is administered than in controls

decreased mast cell degranulation ( J:145444 )

• bone marrow derived mast cells have a 3-fold reduction in granule release upon Fc-epsilionRI stimulation compared to controls

• calcium flux from the extracellular environment is significantly reduced after receptor stimulation compared to controls

• when passive cutaneous anaphylaxis (PCA) is induced in the ear of mice, the mast cells fail to respond

• similar results are observed when mutant mast cells are transferred into mast-cell deficient mice and PCA is induced

cellular

decreased mast cell degranulation ( J:145444 )

• bone marrow derived mast cells have a 3-fold reduction in granule release upon Fc-epsilionRI stimulation compared to controls

• calcium flux from the extracellular environment is significantly reduced after receptor stimulation compared to controls

• when passive cutaneous anaphylaxis (PCA) is induced in the ear of mice, the mast cells fail to respond

• similar results are observed when mutant mast cells are transferred into mast-cell deficient mice and PCA is induced

Allelic Composition	Pak1^tm1Cher/Pak1^tm1Cher
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pak1^tm1Cher mutation (1 available); any Pak1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:195865 )

N	• hematopoietic stem cells exhibit normal migration, homing and engraftment

Allelic Composition	Nf1^tm1Tyj/Nf1⁺ Pak1^tm1Cher/Pak1^tm1Cher
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1^tm1Tyj mutation (3 available); any Nf1 mutation (157 available)
Pak1^tm1Cher mutation (1 available); any Pak1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mast cell physiology ( J:142439 )

• bone marrow derived mast cells proliferate at 60% the rate as controls when cultured for three days with SCF

• migration rates and degranulation of mast cells in response to SCF-treatment is similar to wild-type controls

hematopoietic system

abnormal mast cell physiology ( J:142439 )

• bone marrow derived mast cells proliferate at 60% the rate as controls when cultured for three days with SCF

• migration rates and degranulation of mast cells in response to SCF-treatment is similar to wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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